中国临床药理学杂志2017，Vol.33Issue(6)：502-505,4.DOI:10.13699/j.cnki.1001-6821.2017.06.007
卡前列甲酯栓对减少普通足月阴道分娩患者产后出血的临床疗效
Clinical effects of carboprost methylate suppositorites in general term vaginal delivery patients with postpartum hemorrhage
摘要
Abstract
Objective To analysis the effect of misopmstol,oxytocin nasal spray and carboprost methylate suppositorites on estrogen,nitric oxide (NO),nitric oxide synthase (NOS) and clinical efficacy in patients with general term vaginal delivery.Methods A total of 600 patients with postpartum hemorrhage were randomly divided into group A,group B and group C,200 cases in each group.Group A was given oxytocin nasal spray,per nostril 0.1 mL,twice a day,group B was given misoprostol,200 μg sublingual,group C received carboprost methylate suppositorites 1 mg,anus.After treatment,the serum levels of estradiol (E2),nitric oxide (NO) and nitric oxide synthase (NOS),bleeding volume,clinical efficacy,adverse drug reactions were compared in three groups.Results After treatment,the total effective rates in group A,B and C were 76.50％ (153/200 cases),86.00％ (172/200 cases),90.50％ (181/200 cases),total effective rate of group C significantly higher than group A (P ＜ 0.05).After treatment,estradiol levels of group A,B,C were (14.75 ±2.09),(17.63 ±2.15),(21.82 ±3.09) nmol · L-1.Levels of NO in group A,B,C were (107.83 ± 11.21),(92.42 ± 10.17),(79.25 ±9.89) nmol · L-1.Levels of NOS in group A,B,C were (25.64 ±3.11),(22.56±3.05),(19.63 ±2.28) nmol · L-1(P ＜0.05).And 2 h bleeding volume were (712.43 ± 40.85),(632.43 ± 42.77),(580.74 ± 37.64) mL in group A,B,C;2-24 h bleeding volume were (138.92 ± 17.86),(126.94 ± 12.93),(103.85 ± 11.13) mL in group A,B,C(P ＜0.05).The adverse drug reactions in group A were nasal irritation,nasal bleeding,incidence of adverse drug reactions was 1.50％ (3/200 cases).The adverse drug reactions in group B were mild nausea,vomiting,dizziness,incidence of adverse drug reactions was 2.50％ (5/200 cases).The adverse drug reactions in group C were diarrhea,nausea and vomiting,incidence of adverse drug reactions was 2.00％ (4/200 cases),with no statistical differences (P ＞ 0.05).Conclusions Compared with the treatment of misoprostol and oxytocin nasal spray,the carboprost methylate suppositorites can significantly improve the serum E2 level,reduce serum NO and NOS levels in patients with postpartum hemorrhage and reduce bleeding.关键词
米索前列醇/缩宫素鼻喷剂/卡前列甲酯栓/产后出血/雌激素/一氧化氮/一氧化氮合酶Key words
misoprostol/oxytocin nasal spray/carboprost methylate suppositorites/postpartum hemorrhage/estrogen/nitric oxide/nitric oxide synthase分类
医药卫生引用本文复制引用
黄静莹,陈萱,吕育纯..卡前列甲酯栓对减少普通足月阴道分娩患者产后出血的临床疗效[J].中国临床药理学杂志,2017,33(6):502-505,4.基金项目
泉州市第一医院青年科研课题基金资助项目(2014-QN-60) （2014-QN-60）
