中国临床药理学杂志2017，Vol.33Issue(6)：561-564,4.DOI:10.13699/j.cnki.1001-6821.2017.06.022
丙酸氟替卡松气雾剂对过敏性鼻炎患儿的临床研究
Clinical trial of fluticasone propionate on children with allergic rhinitis
摘要
Abstract
Objective To observe the clinical efficacy of fluticasone propionate aerosol in children with allergic rhinitis and its effect on osteopontin (OPN),interleukin-4 (IL-4) and intedeukin-5 (IL-5)expression.Methods Sixty children with allergic rhinitis were randomly divided into control group and treatment group,30 cases in each group.Control group was treated with ketotifen 1 mg,twice daily.The treatment group was treated with fluticasone propionate aerosol,100 μg each time,twice a day for 2 months.The levels of interleukin (IL)-4,IL-5 and integral optical density (IOD) of immunohistochemical staining of osteopontin in two groups were observed.The clinical effect and the number of eosinophils,neutrophils and lymphocytes in peripheral blood of 1,3,6 months after operation were observed.Results Mter treatment,the levels ofIL-4,IL-5 and OPN in treatment group were (66.31 ± 18.00) ng· mL-1,(62.12 ± 0.33) ng· mL-1,5589.71 ± 267.00,had significant difference with those in control group,which were (85.32 ± 12.34) ng · mL-1,(30.24 ± 0.30) ng · mL-1 and (15.00 ±0.26) + 103(P ＜0.05).The number of eosinophils,neutrophils and lymphocytes in 6 month after treatment in treatment group were (0.21 ±0.01) × 109/L,(0.10 ±0.01) × 109/L,(0.14 ±0.01) + 109/L.The number of eosinophils,neutrophils and lymphocytes in control group at 6 months after treatment were (0.21 ±0.02) + 109/L,(0.10 ±0.01) + 109/L,(0.14 ±0.01) + 109/L respectively,all had significant difference with those in 1 month after treatment (P ＜ 0.05),with no significant between the two groups (P ＞0.05).The total effective rate was 93.33％ (28/30 cases) in treatment group and 36.67％ (11/30 cases) in control group (P ＜0.05).The incidence of adverse drug reaction in treatment group was 3.33％ (1/30 cases).In control group,there were 4 cases of skin allergy,3 cases of thrush,3 cases of bronchospasm with asthma,theincidence of adverse drug reactions was 33.33 ％ (10/30 cases,P ＜ 0.05).Conclusion Fluticasone propionate aerosol treatment of children with allergic rhinitis have significant clinical efficacy.关键词
丙酸氟替卡松气雾剂/过敏性鼻炎/骨桥蛋白/白细胞介素-4/白细胞介素-5Key words
fluticasone propionate aerosol/allergic rhinitis/osteopontin/interleukin-4/interleukin-5分类
医药卫生引用本文复制引用
谭君武,廖勇,彭洪,李良波,孙书菊,於席芳..丙酸氟替卡松气雾剂对过敏性鼻炎患儿的临床研究[J].中国临床药理学杂志,2017,33(6):561-564,4.基金项目
湖北省卫生厅科研一般基金资助项目(JX6B104) （JX6B104）
