中国免疫学杂志2017，Vol.33Issue(4)：481-487,7.DOI:10.3969/j.issn.1000-484X.2017.04.001
CD8+T细胞活化与分化的分子机制
Molecular mechanism of CD8+ T cell activation and differentiation
刘畅 1王红艳1
作者信息
- 1. 中科院上海生物化学与细胞生物学研究所系统生物学重点实验室/中科院分子细胞卓越中心,上海200000
- 折叠
摘要
Abstract
CD8+ T cells play an essential role in defending against viruses,intracellular bacteria,protozoal infections and clearance of tumors since almost all the nucleated cells express MHCⅠ molecule.Following antigen recognition,CD8+ T cells are activated and differentiated to different subsets of effector or memory cells,which could clear the pathogen and form long-term protection.Phenotypic markers,functional properties and anatomical locations are different among these CD8+ T cell subsets.They also show variation in surviving time,proliferation and effector functions when re-challenged with the pathogen or tumor.Multiple signaling pathways and transcriptional factors are involved in CD8+ T cells activation and differentiation,and will be discussed in this review.We will also briefly summary the clinical applications of T cells against tumor or pathogens.关键词
细胞毒性T细胞/活化/分化/记忆T细胞/效应T细胞Key words
Cytotoxic T cell/CTL/Activation/Differentiation/Memory T cell/Effector T cell分类
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刘畅,王红艳..CD8+T细胞活化与分化的分子机制[J].中国免疫学杂志,2017,33(4):481-487,7.
