中国药房2017，Vol.28Issue(10)：1320-1323,4.DOI:10.6039/j.issn.1001-0408.2017.10.06
豨莶草醇提物对多柔比星致小鼠慢性心肌损伤的保护作用
Protective Effects of Ethanol Extracts from Siegesbeckiae herba on Doxorubicin-induced Chronic Myocardi-al Injury in Mice
摘要
Abstract
OBJECTIVE:To explore the effects of extracts from Siegesbeckiae herba (HS) on doxorubicin (DOX)-induced chronic myocardial injury in mice. METHODS:48 mice were randomly divided into 3 groups. Mice in blank control(Con)group received distilled water once every day,ig,and normal saline(2 mL/100 g)once every day,ip,for 8 weeks;mice in DOX mice received distilled water(2 mL/100 g)once every day,ig,and DOX(3 mg/kg)once every week,ip,for 8 weeks;mice in DOX+HS group received HS(340 mg/kg)once every day,ig,and DOX(3 mg/kg)once every week,ip,for 8 weeks. After administra-tion,body mass,heart coefficient,cardiac function changes,serum biochemical index levels [alanine aminotransferase(ALT),as-partate aminotransferase (AST), creatine phosphokinase (CK), creatine kinase isoenzyme (CK-MB), lactate dehydrogenase (LDH)and total cholesterol(TC)] of mice were determined. RESULTS:Compared with Con group,body mass of mice in DOX group was decreased(P<0.01);heart coefficient was increased(P<0.05);heart rate slowed down,R-wave was increased(P<0.05 or P<0.01);serum biochemical indexed were increased,there was significant difference in AST(P<0.01). Compared with DOX group,heart coefficient of mice in DOX+HS group was decreased (P<0.01);heart rate was increased (P<0.01);serum biochemical indexes were decreased,there was significant differences in CK,LDH,TC(P<0.01). CONCLUSIONS:HS has cer-tain protective effects on DOX-induced chronic myocardial injury in mice.关键词
豨莶草醇提物/多柔比星/慢性心肌损伤/小鼠Key words
Ethanol extracts from Siegesbeckiae herba/Doxorubicin/Chronic myocardial injury/Mice分类
医药卫生引用本文复制引用
于静,苏素文,杨继章,何林峰,王可欣,张晓飞..豨莶草醇提物对多柔比星致小鼠慢性心肌损伤的保护作用[J].中国药房,2017,28(10):1320-1323,4.基金项目
国家自然科学基金资助项目(No.81273600) （No.81273600）
河北省自然科学基金资助项目(No.C2011206145) （No.C2011206145）
河北省中医药管理局中医药类科研计划课题(No.2012008) （No.2012008）
