中国药房2017，Vol.28Issue(10)：1382-1385,4.DOI:10.6039/j.issn.1001-0408.2017.10.23
均匀设计筛选吲哚美辛亲水凝胶贴剂的基质处方
Matrix Formulation Screening of Indomethacin Hydrophilic Gel Patch by Uniform Design
摘要
Abstract
OBJECTIVE:To screen the matrix formulation of Indomethacin hydrophilic gel patch. METHODS:Using appear-ance,adhesion,softness,moisture retention as indexes,mixed level of uniform design was used to screen matrix formulation of patch,verification test and in vitro transdermal test were used to evaluate the patch quality. RESULTS:Optimized matrix formula-tion was as follow as PVA of 7.686 g,PVP of 9.662 g,glyceryl of 19.992 g,gelatin of 9.999 g,CMC-Na of 13.997 g,carbomer of 3.000 g,HPMC of 1.500 g. The prepared patch had smooth surface,uniform matrix,good color,strong adhesion,good soft-ness(water loss rate of 11.9%). It can be slowly released for 48 h. The in vitro transdermal release fitted the Higuchi model(R2=0.9869). CONCLUSIONS:Indomethacin hydrophilic gel patch is successfully prepared,which can slowly release drug with over-all good quality.关键词
均匀设计/吲哚美辛/贴剂/基质处方/成型工艺Key words
Uniform design/Indomethacin/Patch/Matrix formulation/Forming technology分类
化学化工引用本文复制引用
谢伟杰,张永萍,徐剑..均匀设计筛选吲哚美辛亲水凝胶贴剂的基质处方[J].中国药房,2017,28(10):1382-1385,4.基金项目
贵州省高层次创新型"百层次人才"培养计划项目(No.黔科合人才〔2015〕4030号) （No.黔科合人才〔2015〕4030号）
贵州省普通高等学校工程研究中心项目(No.黔教合KY字〔2014〕22号) （No.黔教合KY字〔2014〕22号）
