中国药房2017，Vol.28Issue(11)：1466-1470,5.DOI:10.6039/j.issn.1001-0408.2017.11.08
妇产科医院门诊超药品说明书用药情况调查与分析
Investigation and Analysis of Off-label Drug Use in Outpatient Department of Obstetrics and Gynecology Hospital
王先利 1金经 1王萌萌 1杨振宇1
作者信息
- 1. 复旦大学附属妇产科医院药剂科,上海 200090
- 折叠
摘要
Abstract
OBJECTIVE:To provide reference for standardizing off-label drug use and guaranteeing clinical rational use of drugs. METHODS:2400 prescriptions were collected from outpatient department of our hospital during Jan.-Mar. 2016 at regular interval, and then divided into super-indication drug use, out-of-dose drug use, out-of-administration route drug use and out-of-group drug use. The out-of-label drug use were analyzed by reseaching package inserts,domestic and foreign guideline,do-mestic and foreign literature,MICROMEDEX Health Care Series database. RESULTS:There were 219 (9.1%) prescriptions of off-label drug use,involving 12 drug types and 38 items of off-label drug use. In mainly manifested as out-of-indication drug use (219 prescriptions,100%),out-of-group drug use (4 prescriptions,1.8%). All off-label drug use were supported by evidence, among which 9 items(23.7%)of off-label drug use were included in MICROMEDEX. Of all the related off-label drugs,Estradiol valerate tabletes(22.8%),Metformin hydrochloride tablets(17.4%)and Ethinylestradiol and cyproterone acetate tablets(12.3%) were the most common. CONCLUSIONS:All off-label drug use are supported by evidences in outpatient department of our hospi-tal. There are difference in the quality of those evidence. If off-label drug use is necessary in the clinic,it is suggested to fully weigh the advantages and disadvantages and establish related clinical management system and procedure to avoid medical risks and guarantee the safety of drug use.关键词
妇产科/处方/超说明书用药Key words
Obstetrics and gynecology department/Prescription/Off-label drug use分类
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王先利,金经,王萌萌,杨振宇..妇产科医院门诊超药品说明书用药情况调查与分析[J].中国药房,2017,28(11):1466-1470,5.
