中国药房2017，Vol.28Issue(11)：1486-1489,4.DOI:10.6039/j.issn.1001-0408.2017.11.13
非处方药致45例不良反应分析
Analysis of 45 Cases of OTC Drug Induced ADR
摘要
Abstract
OBJECTIVE:To investigate the occurrence of ADR induced by over-the-counter(OTC)drug in order to guide the rational use of drugs. METHODS:45 cases of ADR induced by OTC drug were analyzed retrospectively in terms of patient's gen-eral information,allergic history,allergenic drugs,reason for drug use,route of administration,incubation period,days of hospi-talization,clinical manifestation,treatment,outcome,etc. RESULTS:Among 45 patients,there were 14 male and 31 female. The patients were mainly 20-30 year-old(31.1%). Three patients had previous history of allergy(6.7%). Most ADR were induced by oral drugs(82.2%). Reasons for drug use were mainly disease of respiratory system(23 cases,51.1%). The results of causality as-sessment were positive in 3 patients(6.7%),probable in 35(n=77.8%),and possible in 7 patients(15.6%). ADR were mainly induced by non-steroidal anti-inflammatory drugs (NSAIDs,57.8%),Chinese patent medicine (20.0%),drugs for external use (17.8%). The clinical manifestations mainly included exanthematous drug eruption (33.3%),erythama multiforme drug eruption (24.4%),urticarial drug eruption(13.3%). CONCLUSIONS:NSAIDs are the main allergenic drugs,and ADR induced by OTC traditional Chinese medicine can not be ignored. To improve medical knowledge and skills of the public and the scientific use of OTC drug are beneficial to improve the clinical treatment level.关键词
非处方药/不良反应/合理用药Key words
OTC drug/ADR/Rational drug use分类
医药卫生引用本文复制引用
徐建东,陈强,易娟娟,李自冶,张晓燕..非处方药致45例不良反应分析[J].中国药房,2017,28(11):1486-1489,4.基金项目
上海市虹口区科学技术委员会医学课题(No.虹卫1502-09) （No.虹卫1502-09）
