中国药房2017，Vol.28Issue(12)：1603-1605,3.DOI:10.6039/j.issn.1001-0408.2017.12.06
阿托伐他汀联合苯磺酸左旋氨氯地平治疗老年高血压合并颈动脉斑块的临床观察
Clinical Observation of Atorvastatin Combined with Levamlodipine Besylate in the Treatment of Elderly Patients with Hypertension Combined with Carotid Plaque
摘要
Abstract
OBJECTIVE:To observe the clinical efficacy and safety of atorvastatin combined with levamlodipine besylate in the treatment of elderly patients with hypertension combined with carotid plaque. METHODS:160 elderly patients with hyperten-sion combined with carotid plaque were randomly divided into control group(80 cases)and observation group(80 cases). Control group orally received Atorvastatin tablet 3 mg,qd+compound reserpine tablets 2 tablets,tid;observation group was received Atorv-astatin tablet(the same dosage and usage with control group)+Levamlodipine besylate tablet 2.5 mg,qd. They were treated for 8 months. Antihypertensive efficacy,blood pressure,and carotid intima-media thickness (IMT) before and after treatment,and the incidence of adverse reactions in 2 groups were observed and recorded. RESULTS:The antihypertensive effective rate in observa-tion group was significantly higher than control group,with statistical significance(P<0.05). Before treatment,there was no sig-nificant difference in blood pressure and IMT levels in 2 groups(P>0.05). After treatment,blood pressure and IMT levels in 2 groups were significantly lower than before,and observation group was lower than control group,with statistical significance(P<0.05). And there was no significant difference in the incidence of adverse reactions in 2 groups(P>0.05). CONCLUSIONS:Atorv-astatin combined with levamlodipine besylate shows good efficacy in the treatment of elderly patients with hypertension combined with carotid plaque,which can not only effectively control patients'blood pressure,but also improve atherosclerosis,reversing plaques and does not increase the incidence of adverse veactions.关键词
老年高血压/苯磺酸左旋氨氯地平/颈动脉斑块/阿托伐他汀/利血平/疗效/安全性Key words
Elderly hypertension/Levamlodipine besylate/Carotid plaque/Atorvastatin/Reserpine/Efficacy/Saftey分类
医药卫生引用本文复制引用
张起顺,陈勇,王朝辉,赵俊,吴春芳,李彦明..阿托伐他汀联合苯磺酸左旋氨氯地平治疗老年高血压合并颈动脉斑块的临床观察[J].中国药房,2017,28(12):1603-1605,3.基金项目
国家自然科学基金资助项目(No.81601123) （No.81601123）
