郝雁冰 1王丽 1容宇 1魏东 1李彦明 1陈万生1
作者信息
- 1. 河北北方学院附属第一医院,河北张家口 075000
- 折叠
摘要
Abstract
OBJECTIVE:To compare therapeutic efficacy and safety of different chemotherapy regimens in the treatment of small cell esophageal cancer. METHODS:In retrospective analysis,58 patients with small cell esophageal cancer were divided into group A(18 cases),B(26 cases)and C(14 cases)according to chemotherapy regimens. Group A was given Cisplatin injection 75 mg/m2 intravenously,d1-3+Paclitaxel injection 175 mg/m2,d1-3. Group B was given Cisplatin injection 30 mg/m2 intravenously,d1-3+Et-oposide injection 100 mg/m2,d1-3. Group C was given Vinorelbine tartrate injection 25 mg/m2 intravenously,d1-3+Gemcitabine hydro-chloride for injection 1000 mg/m2,d1-3. A treatment course of 3 groups lasted for 21 d,and they all received 2 cycles of treatment. Clinical efficacies,1,2,3-year survival rate and the incidence of Ⅲ-Ⅳ degree toxic reaction(cough,fever,expectoration,short-ness of breath,fatigue,chest pain,bone marrow suppression,gastrointestinal reactions) were compared among 3 groups. RE-SULTS:Total response rate and 1,2,3-year survival rate were in descending order:group C>group B>group A;the incidence of Ⅲ-Ⅳ degree cough,fever,expectoration,shortness of breath,fatigue,chest pain were in ascending order:group C<group B<group A,with statistical significance(P<0.05). There was no statistical significance in the incidence of Ⅲ-Ⅳ degree myelo-suppression and digestive tract reaction among 3 groups(P>0.05). CONCLUSIONS:Therapeutic efficacy and 1,2,3-year survival rate of vinorelbine combined with gemcitabine are significantly higher than those of cisplatin combined with paclitaxel or etoposide with better safety.关键词
顺铂/紫杉醇/依托泊苷/长春瑞滨/吉西他滨/小细胞食管癌/疗效/安全性Key words
Cisplatin/Paclitaxel/Etoposide/Vinorelbine/Gemcitabine/Small cell esophageal cancer/Therapeutic efficacy/Safety分类
医药卫生
