中国药理学通报2017，Vol.33Issue(4)：465-468,4.DOI:10.3969/j.issn.1001-1978.2017.04.005
钙敏感受体的功能特点及对成体干细胞特性的影响
Functions and characteristics of calcium-sensing receptorsand effects of CaSR on characteristics of adult stem cells
摘要
Abstract
Calcium-sensing receptor(CaSR) is a widely distributed G-protein coupled receptor.The activated CaSR plays an important role in many kinds of signaling pathway regulation, such as Ca2+ signaling pathway.It not only maintains the body calcium balance, but also is involved in the regulation of a variety of cell secretion, proliferation, apoptosis, and ion channel opening processes.CaSR expression is involved in stem cell migration, adhesion and homing in hematopoietic stem cells and mesenchymal stem cells.The activated CaSR also regulated the function of itself and characteristics in stem cells through a variety of cell signaling pathways.We introduce the functions and characteristics of CaSR, the relationship between CaSR and disease, and review the effects of the biological characteristics on hematopoietic stem cells and mesenchymal stem cells.关键词
钙敏感受体/G-蛋白偶联受体/细胞信号通路/造血干细胞/间充质干细胞/人参皂苷Rg1/西那卡塞Key words
calcium sensing receptor/G-protein coupled receptors/cell signaling pathway/hematopoietic stem cell/mesenchymal stem cell/ginsenoside Rg1/cinacalcet分类
医药卫生引用本文复制引用
罗欣,余丽梅..钙敏感受体的功能特点及对成体干细胞特性的影响[J].中国药理学通报,2017,33(4):465-468,4.基金项目
国家自然科学基金资助项目(No 81260507)和贵州省科技厅社发攻关项目资助(黔科合S字[2007]1029) （No 81260507）
