中国药理学通报2017，Vol.33Issue(4)：512-516,5.DOI:10.3969/j.issn.1001-1978.2017.04.013
海星皂苷对非酒精性脂肪肝大鼠肌肉胰岛素信号通路的影响
Effects of starfish saponins on insulinsignaling pathway in muscle of NAFLD rats
摘要
Abstract
Aim To investigate the effects of starfish saponins(Sfs) on insulin signaling pathway in orotic acid-induced NAFLD rats.Methods 1% orotic acid was used to establish NAFLD model in male Wistar rats for six weeks.The NAFLD rats were randomly divided into two groups(eight rats in each group) and then fed with the corresponding diets: Model group(1% orotic acid)and Sfs group(1% orotic acid containing 0.04% starfish saponins).After starfish saponins feeding for 8 weeks, hepatic lipids content, liver function indices and relevant protein expression in muscle insulin signaling pathway were measured.Results Compared with model group, starfish saponins reduced hepatic lipids content and improved liver functions.In addition, it effectively ameliorated insulin resistance by improving insulin signaling pathway and improved glucose uptake in muscle.Conclusion The amelioration effect of starfish saponins on impaired insulin signaling pathway in muscle is observed in orotic acid-induced NAFLD rats.关键词
胰岛素信号通路/肌肉/海星皂苷/葡萄糖/非酒精性脂肪肝/乳清酸Key words
insulin signaling pathway/muscle/starfish saponins/glucose/nonalcoholic fatty liver disease/orotic acid分类
医药卫生引用本文复制引用
陈成,韩秀清,刘春花,李兆杰,薛长湖,王玉明..海星皂苷对非酒精性脂肪肝大鼠肌肉胰岛素信号通路的影响[J].中国药理学通报,2017,33(4):512-516,5.基金项目
国家自然科学基金资助项目(No 31571771) （No 31571771）
新世纪优秀人才支持计划(No NCET-13-0534) （No NCET-13-0534）
