中国医学前沿杂志（电子版）2017，Vol.9Issue(2)：72-75,4.DOI:10.12037/YXQY.2017.02-14
进展期乳腺癌术后多西他赛联合卡培他滨化疗同步放疗的临床研究
Clinical study of advancedbreastcancer postoperative of docetaxel combined with capecitabine chemoth-erapy concurrent with radiotherapy
摘要
Abstract
Objective To explore the clinical effect of docetaxel combined with capecitabine chemotherapy in patients with advanced breast cancer after concurrent radiotherapy. Method 82 cases of advanced breast cancer patients admitted to our hospital from January 2011 to January 2015 were randomly divided into observation group and control group, 41 cases in each group. Observation group patients were treated by docetaxel combined with capecitabine chemotherapy concurrent with radiotherapy, while control group patients only received chemotherapy treatment. Compared the short-term efficacy, follow-up of 1 year and 2 years of survival and recurrence, and adverse reactions occurred between the two groups. Result The total effective rate of observation group was significantly higher than that of control group (P < 0.05). After 1 year of follow-up, there was no significant difference in survival rate between the two groups (P > 0.05). After 2 years of follow-up, the survival rate of observation group was higher than that of control group (P < 0.05). Followed up for 1 year and 2 years, the recurrence rate of observation group were significantly lower than that of control group (P < 0.05). There were no significant differences in the incidence of gastrointestinal reactions, bone marrow suppression, abnormal liver function and reduction of white blood cells in the two groups (P > 0.05). Conclusion The short-term efficacy of docetaxel combined with capecitabine chemotherapy concurrent with radiotherapy in patients with advanced breast cancer is significant, which can prolong the survival time and reduce the recurrence rate.关键词
进展期乳腺癌/多西他赛/卡培他滨/同步放疗Key words
Advanced breast cancer/Docetaxel/Capecitabine/Radiotherapy引用本文复制引用
王轶珊,李云霞,田青,毕清..进展期乳腺癌术后多西他赛联合卡培他滨化疗同步放疗的临床研究[J].中国医学前沿杂志（电子版）,2017,9(2):72-75,4.基金项目
云南省教育厅科学研究基金项目(2014CD41Y) （2014CD41Y）
