中国医学前沿杂志（电子版）2017，Vol.9Issue(2)：88-92,5.DOI:10.12037/YXQY.2017.02-18
肠道菌群与大肠癌发病风险的相关性研究
The study on the relationship between microbial community in intestine and colorectal cancer
摘要
Abstract
Objective To study the level of intestinal flora in colorectal cancer, colorectal adenoma and normal population, and to explore the correlation between intestinal flora and colorectal cancer risk. Method 45 patients with colorectal cancer (colorectal cancer group) and 62 patients with colorectal adenoma (colorectal adenoma group) were enrolled in this study from January 2015 to March 2016, and 60 normal subjects were selected as the control group. The levels of flora were determined by polymerase chain reaction (PCR), and the levels of intestinal microflora were compared between the three groups, in order to analyze the occurrence and development of colorectal cancer. Result The levels of Bifidobacteria and Lactobacilli in colorectal cancer group were significantly lower than those in colorectal adenoma group and control group (P < 0.05), and the levels of Escherichia coli, Enterococcus faecalis and Clostridium were significantly higher than those of control group (P < 0.05). The levels of Enterococcus faecalis, Bacteroides, Fusobacterium, Bacteroides fragilis, Bacteroides uniformis, Bacteroides thetaiotaomicron, Bacteroides ovatus, Bacteroides distasonis, Bacteroides vulgatus, Actinomyces pseudonecrophorus, Clostridium botulinum, and clostridium difficile were significantly higher than those of colorectal adenoma group and control group (P < 0.05). Bifidobacterium and Lactobacillus were negatively correlated with colorectal cancer (P < 0.05). Escherichia coli, enterococcus faecalis, bacteroides, fusobacterium, Bacteroides fragilis Bacteroides thetaiontaomicron, Bacteroides vulgatus, Actinomyces necrophorus, clostridium difficile were positively correlated with colorectal cancer (P < 0.05). Bifidobacterium and Lactobacillus were negatively correlated with TNM staging of colorectal cancer (P < 0.05). Escherichia coli, Bacteroides, Fusobacterium and Bacteroides fragilis were positively correlated with TNM staging of colorectal cancer (P<0.05). Conclusion The status of intestinal flora is related to the occurrence and development of colorectal cancer.关键词
肠道菌群/大肠癌/发病风险/相关性Key words
Intestinal flora/Colorectal cancer/The risk/The correlation引用本文复制引用
潘勇..肠道菌群与大肠癌发病风险的相关性研究[J].中国医学前沿杂志（电子版）,2017,9(2):88-92,5.基金项目
四川省卫计委立项课题(150217) （150217）
