摘要
Abstract
Objective To investigate the clinical value of different ultrasound abnormalities during early pregnancy in screening fetal chromosomal abnormalities. Method Selected 147 pregnant women with abnormal fetus detected by ultrasound in our hospital from April 2006 to April 2016 in the first trimester of pregnancy (gestational age from 11 to 14 weeks). All the pregnant women were analyzed for the karyotype of amniotic fluid or villus. The detection rate of abnormal chromosome in abnormal fetus was statistically analysed. Result Early pregnancy ultrasound abnormality indexes including cardiac malformation, skin edema, nasal catheter, ductus venosus reverse in a wave, the cervical lymphatic hygroma, nuchal translucency (NT) thickening and acromphalus. Chromosomal abnormalities detection rate of cardiac malformation was 80.00% (8/10), with trisomy 18 and trisomy 21; chromosomal abnormalities detection rate of skin edema was 68.00% (17/25), with trisomy 18, 45, X and trisomy 21; chromosomal abnormalities detection rate of nasal abnormal was 75.00% (6/8), with trisomy 18 and trisomy 21; chromosomal abnormalities detection rate of ductus venosus reverse in a wave was 71.43% (5/7), with trisomy 21 and trisomy 18, and 45, X; chromosomal abnormalities detection rate of cervical lymphoma was 66.67% (6/9), with 45, X and trisomy 21; chromosomal abnormalities detection rate of NT thickening was 37.80% (31/82), with trisomy 21, 45, X, and trisomy 18;chromosomal abnormalities detection rate of omphalocele was 66.67% (4/6), with trisomy 21, 45, X, and trisomy 18. Conclusion Abnormal early pregnancy ultrasound prenatal ultrasound is most often detected with cardiac malformation, skin edema, NT thickening and cervical lymphoma,with more of these indicators appearing at the same time the higher the incidence of chromosome abnormality is.关键词
孕早期/超声异常指标/胎儿染色体核型异常Key words
Early pregnancy/Ultrasonic abnormality index/Fetal chromosomal abnormality
