中国药业2017，Vol.26Issue(5)：24-29,6.DOI:10.3969/j.issn.1006-4931.2017.05.006
冠心宁注射液中重金属及有害元素含量测定及消解条件优选
Content Determination of Heavy Metals and Harmful Elements in Guanxinning Injection by Orthogonal Test
朱芹 1黄湘杰2
作者信息
- 1. 湖南省湘潭市食品药品检验所,湖南湘潭 411100
- 2. 湖南省湘乡市人民医院,湖南湘潭 411400
- 折叠
摘要
Abstract
Objective To optimize the content determination method of heavy metals and harmful elements in Guanxinning Injection. Methods Orthogonal test was used, and the injection amount of acid system, maximum temperature of microwave digestion, the duration of maximum temperature microwave digestion and the maximum temperature of acid were taken as the observation factors to determine the content of arsenic and mercury with the design of L9 ( 34 ) graphite furnace atomic absorption spectrophotometry. Determination of ar-senic and mercury was done by hydride atomic absorption spectrophotometry;determination of copper was done by air-acetylene flame atomic absorption spectrophotometry. Results The optimum digestion condition was that the acid system was HNO3 : H2O2 ( 6 :2 ) , the maximum digestion temperature was 120 ℃ for 30 min, and the correlation coefficient r > 0. 9995 of the five elements with acid temperature of 120 ℃. Conclusion The method is accurate and rapid with good operability and small interference as well as reliable results, which can be used for the quality control of heavy metals and harmful elements in Guanxinning Injection.关键词
重金属及有害元素/正交试验/冠心宁注射液/原子吸收光谱/消解条件Key words
heavy metals and harmful elements/orthogonal test/Guanxinning Injection/atomic absorption spectrometry/digestion condition分类
医药卫生引用本文复制引用
朱芹,黄湘杰..冠心宁注射液中重金属及有害元素含量测定及消解条件优选[J].中国药业,2017,26(5):24-29,6.
