中国药业2017，Vol.26Issue(6)：9-11,3.DOI:10.3969/j.issn.1006-4931.2017.06.003
氨来呫诺口腔贴片的制备、黏附及释药特性评价
Preparation,Adhesion and Drug Release Characteristics of Amlexanox Buccal Tablets
摘要
Abstract
Objective To optimize the preparation process of Amlexanox Buccal Tablets(ABT)and to evaluate its adhesion and release characteristics. Methods ABT was prepared by direct powder compression using carbomer 71GNF and mannitol 200SD as auxiliary ma-terial. Egg film was used to substitute oral mucosa. The modified paddle experiment was applied to determine drug release rate. The dis-integration time was tested according to Chinese pharmacopoeia method. The in vivo tests were carried out by healthy volunteers to de-termine the adhesion and release characteristics. Results The optimal ratio of carbomer 71GNF and mannitol 200SD was 1 :1. 5. Drug release rate and the adhesion time in vivo had good correlation with in vitro. Conclusion Direct powder compression technology for the preparation of ABT is simple,reproducible and suitable for industrial production. The modified paddle experiment and disintegration test can be used to predict in vivo drug release rate and adhesive time.关键词
粉末直接压片/氨来呫诺/口腔贴片/黏附性/释放度Key words
direct powder compression/amlexanox/buccal tablets/adhesive ability/release rate分类
医药卫生引用本文复制引用
毕诗涛,李雪梅,符旭东..氨来呫诺口腔贴片的制备、黏附及释药特性评价[J].中国药业,2017,26(6):9-11,3.基金项目
湖北省武汉市科技攻关计划项目[201161038346]. （）
