中国药业2017，Vol.26Issue(6)：34-37,4.DOI:10.3969/j.issn.1006-4931.2017.06.010
丝裂霉素C联合顺行泪道引流管植入治疗上泪道阻塞临床研究
Clinical Study of Mytomycin C Combined with Anterograde Lacrimal Duct Drainage Tube Implant in Treating Upper Lacrimal Duct Obstruction
摘要
Abstract
Objective To investigate the clinical efficacy of mitomycin C(MMC)in lacrimal duct drainage tube implant treatment of up-per lacrimal duct obstruction. Methods Totally 166 patients(188 eyes)with upper lacrimal duct obstruction were selected and randomly divided into the control group and the treatment group according to different therapy methods. The control group(40 cases,44 eyes)was only implanted anterograde lacrimal duct drainage tube;on this basis,the treatment group(126 cases,144 eyes) were added MMC. The treatment group was divided into 6 groups according to the mass concentration and retention time of MMC. The mean follow-up was (16. 25 ± 3. 24) months(6~20 months),the clinical efficacy between the two groups and among the 6 groups in the treatment were compared. Results The difference of the total effective rate in the two groups had statistical significance(χ2=15. 29,p < 0. 05);in the 6 groups,the effective rate of each group was compared,there was significant difference between the C1 group and the control group (χ2=9. 170,p < 0. 01). There was no adverse reaction and complication in each group. Conclusion Mytomycin C combined with anterograde lacrimal duct drainage tube implant in treating upper lacrimal duct obstruction can improve the cure rate,and anterograde lacrimal duct drainage tube injected with 0. 1 mL MMC ( 0. 3 g/L ) for 3 minutes has better effect.关键词
上泪道阻塞/泪道引流管/丝裂霉素C/临床疗效Key words
upper lacrimal duct obstruction/acrimal duct drainage tube/Mytomycin C/clinical effect分类
医药卫生引用本文复制引用
邓宗勇,杨学兵,曹凤芝,万文娟,刘伟,欧升聪,冯斌炜,唐崑源,刘佩..丝裂霉素C联合顺行泪道引流管植入治疗上泪道阻塞临床研究[J].中国药业,2017,26(6):34-37,4.基金项目
2015年重庆市卫生计生委医学科研项目[2015MSXM190]. （）
