中国中西医结合外科杂志2017，Vol.23Issue(1)：3-6,4.DOI:10.3969/j.issn.1007-6948.2017.01.001
可溶性髓样细胞触发受体-1与自发性腹膜炎肠黏膜通透性的关系
Association of Soluble Triggering Receptor Expressed on Myeloid Cell-1 with Intestinal Mucosal Permeability in Patients with Spontaneous Bacterial Peritonitis
摘要
Abstract
Objective To investigate association of soluble triggering receptors expressed by myeloid cell-1 (sTREM-1) on intestinal mucosal permeability in cirrhotic patients with spontaneous bacterial peritonitis (SBP).Methods Twenty-three patients with SBP were taken as SBP group,the concurrent 33 cirrhotic ascites patients without SBP were taken as non-SBP group,and 20 healthy cases as healthy control group.The serum and ascitic fluid levels of sTREM-1 were measured,the levels of urinary excretion of LAC/MAN ratios were calculated.Results The sTREM-1 concentration of (217.28± 87.65) pg/mL in serum and (218.76±69.38) pg/mL in ascites in SBP group were both higher than those in non-SBP group [(55.51±14.28) pg/mL,(75.98±21.57) pg/mL,respectively] with statistical differences between the two groups (P ＜ 0.05).The levels of the serum and ascitic fluid sTREM-1 had significantly correlated with the levels of urinary excretion of LAC/MAN ratios(rserum=0.518,rascites=0.527,P ＜ 0.05),and the levels of the serum and ascitic fluid sTREM-1 had significantly correlated with Child-Pugh classification(rserum =0.791,rascites=851).Conclusion sTREM-1 may promote intestinal mucosal permeability in patients with SBP,and is also associated with the degree of intestinal permeability damage and impaired liver function.关键词
可溶性髓样细胞触发受体-1/自发性细菌性腹膜炎/肠黏膜通透性Key words
Soluble triggering receptor expressed on myeloid cell-1/spontaneous bacterial peritonitis/intestinal mucosal permeability分类
医药卫生引用本文复制引用
张晓苹,赵宏军,马阿火,秦月花,孙爱静,王晓丽,王兴木..可溶性髓样细胞触发受体-1与自发性腹膜炎肠黏膜通透性的关系[J].中国中西医结合外科杂志,2017,23(1):3-6,4.基金项目
浙江省绍兴市科技局基金项目资助(2013B70078) （2013B70078）
