中国中西医结合外科杂志2017，Vol.23Issue(2)：118-121,4.DOI:10.3969/j.issn.1007-6948.2017.02.004
凋亡抑制蛋白和紧密连接蛋白4在前列腺癌中的表达及与前列腺癌临床病理特征的关系
Expression and Significance of Livin and Claudin-4 Protein in Prostate Cancers with Tissue Microar- ray
摘要
Abstract
Objective To explore the relationship of clinical pathological characteristics and expression of Livin and Claudin-4 protein in prostate cancers. Methods Tissue microarray technology was used for detect tissues for 71 cases with prostate cancer and 37 patients with benign prostatic hyperplasia. Total 64 paraffin mi-assess the relationship between expression of Livin and Claudin-4. Results The positive expression rates of Livin and Claudin-4 in benign prostatic hyperplasia tissues were significantly lower than those in prostate can-cer tissues (P<0.01). The positive expression rates of Livin in prostate cancer tissues were 56.41% (22/39) (Gleason score<7) and 81.25% (26/32) (Gleason score≥7). The positive expression rates of Livin were 56.10%(23/41) in stage Ⅰ~Ⅱ and 83.33%(25/30) in stage Ⅲ~Ⅳ, respectively. The positive expression rates of Claudin-4 were in prostate cancer tissues were 43.59(17/39) for Gleason score<7 and 75.00(24/32) for Gleason Score ≥7. For stage Ⅰ~Ⅱ and Ⅲ~Ⅳ, the expression of Claudin-4 were 60.98%(25/41) and 80.00%(24/30), respectively. The expression of Livin and Claudin-4 was positively correlated by Spearmanˊs rank correlation (r = 0.87). Conclusion Abnormal expression of Livin and Claudin-4 protein may be involved in generation and develop-ment of prostate cancer. Combined detection can assess the prognosis of prostate cancer.关键词
前列腺癌/凋亡抑制蛋白/紧密连接蛋白-4/组织芯片/免疫组织化学Key words
Prostate cancer/livin/claudin-4/tissue microarray/immunohistochemistry分类
医药卫生引用本文复制引用
张春霆,朱再生..凋亡抑制蛋白和紧密连接蛋白4在前列腺癌中的表达及与前列腺癌临床病理特征的关系[J].中国中西医结合外科杂志,2017,23(2):118-121,4.基金项目
浙江省金华市科学技术研究计划项目资助(2013-3-043) （2013-3-043）
