中国中医药信息杂志2017，Vol.24Issue(5)：67-70,4.DOI:10.3969/j.issn.1005-5304.2017.05.016
醋制南五味子对2型糖尿病大鼠脂代谢的影响
Effects of Vinegar Fructus Schisandrae Sphenantherae on Lipid Metabolism in Rats with Type 2 Diabetes
摘要
Abstract
Objective To investigate the effects of Schisandrae Sphenantherae Fructus and processed with vinegar on lipid metabolism of rats with type 2 diabetes mellitus (T2DM). Methods The rat model of T2DM was induced by high fat diet plus STZ. The rats were randomly divided into blank group, model group, Schisandrae Sphenantherae Fructus high-dose group and low-dose group, and vinegar Schisandrae Sphenantherae Fructus high-dose group and low- dose group. The rats in each group were fed with the corresponding medicine for gavage for 30 d. FINS, FFA, TC, TG, HDL-C, LDL-C, and MDH, total protein content of liver tissue were detected. HE staining was used to observe the histomorphological changes of liver and pancreas in rats. Results Compared with the model group, Schisandrae Sphenantherae Fructus groups and vinegar Schisandrae Sphenantherae Fructus groups did not show obvious effects on improving FBG and FINS, but it could raise varying degrees of HDL-C and MDH, and reduce FFA, LDL-C, TC, and TG, among which vinegar Schisandrae Sphenantherae Fructus could significantly regulate metabolism in T2DM rats. Conclusion Vinegar Schisandrae Sphenantherae Fructus can enhance the lipid metabolism regulatory function of T2DM rats.关键词
南五味子/醋制/2型糖尿病/脂代谢/大鼠Key words
Schisandrae Sphenantherae Fructus/processing with vinegar/type 2 diabetes/lipid metabolism/rats分类
医药卫生引用本文复制引用
邓翀,姜祎,张化为,刘继平,柴思佳,侯建平..醋制南五味子对2型糖尿病大鼠脂代谢的影响[J].中国中医药信息杂志,2017,24(5):67-70,4.基金项目
国家自然科学基金(30902002、81374028) （30902002、81374028）
陕西省中医药管理局资助项目(13-ZY014) （13-ZY014）
