中华临床免疫和变态反应杂志2017，Vol.11Issue(1)：26-31,6.DOI:10.3969/j.issn.1673-8705.2017.01.005
空气中粒径小于等于10微米颗粒物对成人哮喘患者肺功能的影响
Effect of Exposure in Particulate Matter Equal or Less than 10 μm in AerodynamicDiameter on Lung Function of Adult Patients with Asthma
摘要
Abstract
Objective To investigate whether the exposure of particulate matter ≤ 10 μm in aerodynamic diameter (PM10) has any impact on lung function in adult patients with asthma.MethodsSeventeen asthma adults from inhabitants of Beijing were recruited and followed up for 9 months, they received at least two spirometry tests every three months in the meanwhile.Twenty-six corresponding data of spirometry test at the beginning and the end of 3 months period were collected.The association between the variation of lung function in three months and the average exposure of PM10 during the corresponding period was analyzed.The six lung function parameters used in analysis were pre-bronchodilator forced expiratory volume in 1 second expressed as percent predicted (Pre FEV1%), pre-bronchodilator forced vital capacity (Pre FVC%) expressed as percent predicted, pre-bronchodilator FEV1/FVC (Pre FEV1/FVC), post-bronchodilator FEV1 expressed as percent predicted (Post FEV1%), post-bronchodilator FVC expressed as percent predicted (Post FVC%), and post-bronchodilator FEV1/FVC (Post FEV1/FVC).The changes of these parameters during the observation period were defined as ΔPre FEV1%, ΔPre FVC%, ΔPre FEV1/FVC, ΔPost FEV1%, ΔPost FVC%, and ΔPost FEV1/FVC respectively.The discrepancy between lung function and PM10 exposure is analyzed using independent-samples t test or nonparametric rank-sum test.Results The participants were divided into the relatively higher PM10 exposure group [(98.00±10.99) g/m3, n=13] and relatively lower PM10 exposure group [(79.23±6.30) g/m3, n=13] based on the median value within three months of the observation period.The ΔPre FEV1%, ΔPre FEV1/FVC ,ΔPost FVC% and ΔPost FEV1/FVC of participants with relatively higher PM10 exposure[the four variations were (-6.96±10.49)%,(-3.79±7.92)%,(-4.07±5.72)%,and (-2.85±5.14)%] showed significant reduction(P values were 0.005, 0.016, 0.004, 0.020), compared with the relatively lower PM10 exposure participants[the four variations were (4.32±12.02)%,(2.22±5.38)%,(7.61±12.66)%,(7.79±7.93)%].The ΔPre FVC%[the variations were (-4.62±8.83)%, (2.63±13.49)% respectively],ΔPost FVC% [the variations were (-2.65±6.74)%, (0.28±13.58)% respectively] presented a downtrend in participants with relatively higher PM10 exposure but there is no significant difference between the two groups statistically.Conclusion The long term PM10 exposure has a negative effect on the pulmonary ventilation function of asthma adults.关键词
粒径小于等于10微米细颗粒物/哮喘/肺功能Key words
particulate matter≤10μm in aerodynamic diameter/asthma/lung function分类
医药卫生引用本文复制引用
王俊,徐凯峰,徐文帅,吴秀秀,高楠楠,田欣伦,张腾越,李伟,黄靖婧,李雪..空气中粒径小于等于10微米颗粒物对成人哮喘患者肺功能的影响[J].中华临床免疫和变态反应杂志,2017,11(1):26-31,6.基金项目
科技部国家重点基础研究计划(973项目)(2015CB553402) （973项目）
