中华临床免疫和变态反应杂志2017，Vol.11Issue(1)：37-41,5.DOI:10.3969/j.issn.1673-8705.2017.01.007
调节性B细胞与系统性红斑狼疮
Regulatory B cell and Systemic Lupus Erythematosus
朱丽 1何岚1
作者信息
- 1. 西安交通大学第一附属医院风湿免疫科, 西安 710061
- 折叠
摘要
Abstract
Systemic lupus erythematosus is a chronic multisystem autoimmune disorder.Auto-reactive B cells play a key role in pathogenesis of systemic lupus erythematosus.B cells have been considered as positive regulators of immune responses in systemic lupus erythematosus by producing antibodies and presenting antigens.While in the past four decades, investigators have found a new capacity of B cells as negative regulator for immune responses.This kind of B cells, named as regulatory B cells(Bregs), may induce immune tolerance and prevent the proliferation of T cells by producing regulatory cytokines IL-10,IL-35, and TGF-β.Here we discuss the current knowledge on the regulatory B cells, with focus on the relationship between SLE and regulatory B cells.关键词
B淋巴细胞/红斑狼疮,系统性/白细胞介素10Key words
B-lymphocytes/lupus erythematosus/systemic/interleukin-10分类
医药卫生引用本文复制引用
朱丽,何岚..调节性B细胞与系统性红斑狼疮[J].中华临床免疫和变态反应杂志,2017,11(1):37-41,5.
