摘要
Abstract
Recently, the promotion of Treat to Target has significantly improved the outcome of rheumatoid arthritis(RA) patients.Thus it is important to make continuous effort to find a better assessment of disease activity.It is proven that cytokines were largely contribute to the pathogenesis of RA.A new assessment of disease activity in terms of cytokines might be an objective measurement for RA disease activity.Michael Centola et al chose 12 biomarkers, including EGF, VEGF-A, leptin, resistin, IL-6, SAA, CRP, VCAM-1, MMP-1, MMP-3, TNFR1 and YKL-40 from 396 biomarkers, to measure the disease activity, which were called multi-biomarker disease activity (MBDA) score.Some studies revealed that MBDA score was significantly associated with DAS28-ESR, DAS28-CRP, CDAI, SDAI, HAQ and ACR/EULAR Boolean remission standard.Compared with traditional assessment methods, MBDA score is also advanced in disease activity assessment, predicting radiographic outcome and guide the management, however, it needs further study.关键词
关节炎,类风湿/多生物学标记疾病活动性评分/目标治疗/疾病活动度/影像学进展Key words
arthritis/rheumatoid/multi-biomarker disease activity score/treat-to-target/disease activity/radiological progression分类
医药卫生
