中山大学学报（医学科学版）2017，Vol.38Issue(2)：177-183,7.
血管平滑肌细胞的容积调节Cl-通道生物学特性及功能研究进展
Research Progress on Biological Characteristics and Function of Volume Regulated Cl-Channel in Vascular Smooth Muscle Cells
摘要
Abstract
Volume regulated chloride channel (VRCC) enhances cell proliferation through PI3K/Akt signal pathway ,and inhibits cell apoptosis through mitochondrial pathway in vascular smooth muscle cells ,and accelerates the process of atherosclerosis through JNK/p38 MAPK signal pathway,resulting in increasing SR-A expression and ox-LDL uptake. Cerebrovascular remodeling is mediated by VRCC. This effect of VRCC on remodeling is related to accelerating cell proliferation ,migration and accumulation of. extracellular matrix. As to the molecular identification of VRCC ,it is very complex. VRCC is diversity in various cells or tissues , rather than a single ubiquitous channel,VRCC may be contain variedcell type-or tissue-specific subunitcompositions. ClC-3 volume regulated Cl-channel is regulated by both integrin-Src and Rho/RhA-Rock signal pathways.关键词
血管平滑肌细胞/容积调节Cl-通道/ClC-3/LRRC8A/Bestrophin/脑血管重构/细胞增殖/细胞凋亡Key words
vascular smooth muscle cell/volume regulated chloride channel/ClC-3/LRRC8A/Bestrophin/cerebrovascular remodeling/cell proliferation/apoptosis分类
医药卫生引用本文复制引用
关永源..血管平滑肌细胞的容积调节Cl-通道生物学特性及功能研究进展[J].中山大学学报（医学科学版）,2017,38(2):177-183,7.基金项目
国家自然科学基金重点项目(81230082 （）
81230082) （）
