中山大学学报（医学科学版）2017，Vol.38Issue(2)：189-195,7.
囊性纤维化跨膜转导调节因子(CFTR)氯通道对心血管功能影响的研究进展
CFTR in Cardiovascular Functions
摘要
Abstract
Cystic fibrosis transmembrane conductance regulator(CFTR)is an ATP-gated,cAMP-dependent chloride channel. The basic biophysical and pathological functions of CFTR are related with the secretion of chloride ion in epithelial cells and tissues. Mutations in CFTR cause cystic fibrosis(CF),which is a rare but fatal autosomal recessive inheritant disease ,mainly affecting glan?dular epithelial function in respiratory tract ,intestinal and reproductive system. New drugs targeting human CFTR gene mutations have been developed to significantly prolong lifeand improve respiratory symptoms of CF patients. Recent evidence suggested that CFTR plays a functional role in vasoconstriction and the formation of myocardial action potential. As a channel protein ,CFTR may al?so functions as a multiprotein/channel complex ,which has been demonstrated in the development of cardiovascular diseases such as myocardial ischemia and pulmonary hypertension.关键词
囊性纤维化跨膜传导调节因子/囊性纤维化/氯离子通道/心肌/血管平滑肌Key words
CFTR/cystic fibrosis/chloride channel/cardiac myocytes/vascular smooth muscle cells分类
医药卫生引用本文复制引用
王冠蕾..囊性纤维化跨膜转导调节因子(CFTR)氯通道对心血管功能影响的研究进展[J].中山大学学报（医学科学版）,2017,38(2):189-195,7.基金项目
基金资助:国家自然科学基金委员会(NSFC)与加拿大卫生研究院(CIHR)健康研究合作计划项目(81361128011) （NSFC）
国家自然科学基金(81370897) （81370897）
广东省科技计划项目(2016A050502023) （2016A050502023）
