中山大学学报（医学科学版）2017，Vol.38Issue(2)：196-203,8.
内质网应激与肾脏疾病
Endoplasmic Reticulum Stress and Kidney Diseases
摘要
Abstract
The endoplasmic reticulum(ER),a main organelle,which regulates protein synthesis,folding and degradation via the unfolded protein response(UPR)pathway. The adaptive UPR pathway predominantly maintains the ER function or ER proteosta?si through three intracellular signaling pathways. Long-term or severe ER stress induces the apoptotic UPR pathway to eliminate dysfunctional cells. Dysregulation of the UPR pathway often occurs in glomerular or tubulointerstitial cells under a pathogenic microen?vironment,such as ischemia,hypoxia,toxin,glucose,and abnormal lipid levels. A defective UPR is highly deleterious to renal cell function and is thereby implicated in the pathophysiology of various kidney diseases. Restoration of normal proteostasis holds promise in protecting the kidney from pathogenic injuries.关键词
内质网应激/肾小管/饱和脂肪酸/锂Key words
endoplasmic reticulum stress/renal tubular cells/saturated fatty acid/lithium分类
医药卫生引用本文复制引用
王蔚东..内质网应激与肾脏疾病[J].中山大学学报（医学科学版）,2017,38(2):196-203,8.基金项目
国家自然科学基金(81370822,81570635,81670646) （81370822,81570635,81670646）
广东省自然科学基金重点项目(2014A020212623,2014A030313168, 2016A020215034) （2014A020212623,2014A030313168, 2016A020215034）
