中山大学学报（医学科学版）2017，Vol.38Issue(2)：204-214,11.
靶向诱导内皮细胞凋亡抑制肿瘤血管新生的研究进展
Inhibition of Tumor Angiogenesis by Targeted Induction of Endothelial Cell Apoptosis
摘要
Abstract
Angiogenesis is one of the important pathological characteristics in the development of tumor growth. Hence ,an?ti-angiogenes is has become a hot topic in the field of cancer research. The current strategy for anti-angiogenesis therapy is to restore the angiogenic balance which is broken in the tumor via either block of proangiogenic factorsor application of angiogenic inhibitors. Endogenous angiogenic inhibitors show more promising prospects compared with proangiogenic factor antagonists. However ,the un?derlying mechanisms for the angiogenic inhibitors remain to be thoroughly elucidated. There are two kinds of endogenous angiogenic inhibitors,one is the hydrolyzed fragments of precursor protein,such as plasminogen Kringle 5(K5),angiostatin/kringle 1~4,end?ostatin,etc;the other is cell secreted proteins,such as pigment epithelium-derived factor(PEDF),kallikrein-binding protein (KBP/kallistatin),antithrombin,etc. Here we summarized the research progresses on the biological functions,underlying mecha?nisms of tumor angiogenesis and application prospects of K5,PEDF,and KBP,so as to provide insights into the antiangiogenic ther?apies of tumor in the future.关键词
肿瘤/血管新生/内皮细胞凋亡/K5/PEDF/KBPKey words
tumor/angiogenesis/endothelial cell apoptosis/K5/PEDF/KBP分类
医药卫生引用本文复制引用
杨霞..靶向诱导内皮细胞凋亡抑制肿瘤血管新生的研究进展[J].中山大学学报（医学科学版）,2017,38(2):204-214,11.基金项目
国家自然科学基金(81272515,81572342) （81272515,81572342）
科技部新药创制重大专项(2013ZX09102-053) （2013ZX09102-053）
教育部高等学校博士学科点专项科研基金(20130171110053) （20130171110053）
广东省自然科学基金(2014A030313073,2016A030311035) （2014A030313073,2016A030311035）
广东省高等学校高层次人才项目 （）
