中山大学学报（医学科学版）2017，Vol.38Issue(2)：222-228,7.
肿瘤糖代谢紊乱的研究进展和探索
Recent Proceedings in Research of Tumor-associated Disorders of Glucose Metabolism
摘要
Abstract
Metabolic rearrangement is a typical hallmark of cancer cells ,especially the disorders in glucose metabolism. Normal cells rely on the steps of oxidative phosphorylation within the mitochondria to metabolize glucose and yield energy upon enough oxygen ,yet turning to glycolysis in the absence of oxygen . Nevertheless ,tumor cells exhibit high levels of glycolytic flux in different environments ,due to the requirement of malignant proliferation. This phenomenon was named as the Warburg effect ,the initiation of which is driven by multiple mechanisms ,including the influence of tumor microenvironment ,the activa?tion of tumor-promoting signaling pathways ,and the aberrant levels of metabolic enzymes. Moreover ,our recent findings sug?gest that inhibition of gluconeogenesis ,the general reversal of glycolysis ,would further promote the Warburg effect and tumor progression.关键词
肿瘤代谢/瓦伯格效应/糖酵解/糖异生/果糖-1,6-二磷酸酶Key words
tumor metabolism/the Warburg effect/glycolysis/gluconeogenesis/fructose-1/6-bisphosphatase分类
医药卫生引用本文复制引用
李博..肿瘤糖代谢紊乱的研究进展和探索[J].中山大学学报（医学科学版）,2017,38(2):222-228,7.基金项目
国家自然科学基金优秀青年科学基金(81622034) （81622034）
国家自然科学基金面上项目(81572508) （81572508）
