中山大学学报（医学科学版）2017，Vol.38Issue(2)：278-284,7.
不同降调节长方案GnRH-a剂量与LH水平的关系及临床结局的比较
Relation between Dosage of GnRH-a and Serum LH Levels and Comparison of Clinical Outcomes among Different GnRH-a Long Protocols
摘要
Abstract
[Objective]To observe the dynamic changes of serum LH levels in different GnRH-along protocols ,and investigate the relationship between GnRH-adosage and LH levels ,and compare the clinical outcomes among different GnRH-a long protocols.[Methods]In this retrospective study,1.0 mg,0.8 mg,0.375 mg long-acting and 0.1 mg/d,0.05 mg/d short-acting GnRH-a long protocols were included from January to June in 2015 at the Reproductive Medicine Center of the First Affiliated Hospital of Sun Yat-Sen University. Serum LH levels were evaluated from a total of 250 women at the four time points,on the day before gonadotropin stimulation(Gn0),the fourth day of Gn stimulation(Gn4),the seventh day of Gn stimulation(Gn7),and the HCG administration day(HCG day),then the relationship between serum LH levels and the dosage of GnRH-a were analyzed. The number of oocytes retrieved,fertilization rate,good quality embryos rate,blastocyst transferred rate,the number of transferred embryos,implantation rate and clinical pregnancy rate were also compared.[Results]Among the long-acting groups,LH levels in 0.375 mg group were higher than those in 1.0 mg and 0.8 mg groups at the four time points(P<0.05). Total Gn dose,duration of Gnstimualtion and HMG dosage of 1.0 mg protocol and 0.8 mg protocol were significantly higher than those of 0.375 mg group(P < 0.05). In addition,the implantation rate showed an increasing tendency when the level of LH increases(P>0.05). In short-acting groups,the LH levels in 0.05 mg/d protocol were significantly lower than those in the 0.1 mg/d group at Gn0,Gn7 and HCG day(P<0.05). Total Gn dose,du?ration of Gn stimulation and HMG dosage did not show significant difference between 0.05mg and 0.1mg group. What′s more,the im?plantation rate in 0.1 mg/d group was higher than in 0.05 mg/d group(P>0.05).[Conclusion]Among the long-acting groups,the smaller amount of GnRH-a was administrated ,the higher LH levels during ovarian stimulation and implantation rate the patients ob?tained. As to the short-acting groups,the LH level and implantation rate in 0.1 mg/d group is higher than those in 0.05 mg/d group.关键词
促性腺激素释放激素激动剂/黄体生成素/胚胎种植率Key words
gonadotropin-releasing hormone agonist/luteinizing hormone/implantation rate分类
医药卫生引用本文复制引用
罗颖怡,邓明芬,胡晓坤,李宇彬,黄可珺,麦庆云..不同降调节长方案GnRH-a剂量与LH水平的关系及临床结局的比较[J].中山大学学报（医学科学版）,2017,38(2):278-284,7.基金项目
中山大学重大项目培育和新兴、交叉学科资助计划(16ykjc10) （16ykjc10）
广州市生殖医学临床医学研究与转化中心试点建设项目(155700011) （155700011）
广东省生殖医学重点实验室项目(2012A061400003) （2012A061400003）
