中山大学学报（医学科学版）2017，Vol.38Issue(2)：307-314,8.
广州地区老年汉族人群CYP2C19基因多态性分布及不同人群间的比较研究
Distribution of Genetic Polymorphisms about CYP2C19 Gene in the Elderly Chinese Han Populations of Guangzhou and the Comparison in Different Populations
摘要
Abstract
[Objective]To investigate the genetic polymorphisms of the CYP2C19 gene in the elderly Chinese Han populations of Guangzhou,and compare the frequencies of CYP2C19 gene polymorphisms in different populations,in order to provide accurate data for the appropriate prescription.[Methods]To detect the genetic polymorphisms of the CYP2C19 gene by the DNA microarray,and compare the frequencies of CYP2C19 gene polymorphisms in Chinese Han populations from different areas and the different races.[Results]There were 2312 case samples in our study. The allele frequencies of CYP2C19*1,CYP2C19*2 and CYP2C19*3 were 64.27%,30.75%,and 4.98%,respectively. As the genotype,EM(*1/*1)was 41.44%(n=958),IM(*1/*2,*1/*3)was 45.67%(n=1056),and PM(*2/*2,*2/*3 and*3/*3)was 12.89%(n=298). The ratios of EM and IM in Chinese Han populations from different areas and all the subtypes of the CYP2C19 genotype in different minority were statistically significant. As the races,there were difference in all the subtypes of the CYP2C19 genotype when Asian populations were compared with white races(P<1304.64)and black races(P<0.01),which was also statistically significant.[Conclusions]The distributions of the CYP2C19 gene polymorphisms were significantly different in Chinese han populations and in different races,and the main subtypes of the CYP2C19 genotype in the elderly of Chinese han populations were IM and EM,which is beneficial for prescribing appropriate in the elderly populations.关键词
CYP2C19/基因多态性/老年/汉族/合理用药/广州Key words
CYP2C19/gene polymorphism/Chinese Han/elderly/appropriately prescribing/Guangzhou分类
医药卫生引用本文复制引用
肖旋浩,曾涛,雷秀霞,李泽,周进,汪志远,潘小平..广州地区老年汉族人群CYP2C19基因多态性分布及不同人群间的比较研究[J].中山大学学报（医学科学版）,2017,38(2):307-314,8.基金项目
广东省自然科学基金(2014A030310093) （2014A030310093）
广州市科技计划项目(2012J5100039) （2012J5100039）
广东省医学科学技术研究基金(B2014339) （B2014339）
