中药材2016，Vol.39Issue(10)：2334-2338,5.DOI:10.13863/j.issn1001-4454.2016.10.043
网络药理学方法研究广藿香治疗肠易激综合征的分子作用机制
Study on Molecular Mechanism of Pogostemon cablin Intervening Irritable Bowel Syndrome Using Network Pharmacology Methods
摘要
Abstract
Objective:To explore the molecular mechanism of Pogostemon cablin on intervening irritable bowel syndrome (IBS) based on computing network pharmacological studies.Methods:The interactions between 94 compounds from Pogostemon cablin and ten approved drug targets related to IBS were studied by molecular docking and network pharmacological analysis methods.Results:Most of the compounds in Pogostemon cablin exhibited good drug-like properties.By the network analysis,the mechanism was revealed that the flavonoids in Pogostemon cablin regulated the ADRB3,CHRM1,CCKAR,HTR4,TACR1 for the treatment of irritable bowel syndrome.Conclusion:The network pharmacological method is an efficient way to predict the active molecules in Pogostemon cablin and to elucidate the mechanism of their action.关键词
广藿香/网络药理学/肠易激综合征/分子对接Key words
Pogostemon cablin (Blanco) Benth./Network pharmacology/Irritable bowel syndrome/Molecular docking分类
医药卫生引用本文复制引用
任恒鑫,孙长海,李云超,张舒婷,牟立婷,刘夕琳..网络药理学方法研究广藿香治疗肠易激综合征的分子作用机制[J].中药材,2016,39(10):2334-2338,5.基金项目
黑龙江省教育厅科研项目(12541809) （12541809）
