中国现代中药2017，Vol.19Issue(2)：196-199,213,5.DOI:10.13313/j.issn.1673-4890.2017.2.007
玉女煎对大鼠佐剂性关节炎的治疗作用及机制研究
Study on Effect and Mechanism of Yunüjian on Adjuvant Arthritis Rat
摘要
Abstract
Objective:To investigate the effect and mechanism of Yunüjian on the arthritic rat.Methods:The adjuvant arthritis rat model was established by injecting the complete Frund's adjuvant into the subcutis of their left rear paws.Rats were randomly divided into control group,adjuvant arthritis(AA) model group,tripterygium glycosides group,Yunüjian highdose(6.1 g herbs·kg-1)group,Yunüjian middle-dose(3 g herbs·kg-1)group,and Yuniüjian low-dose(1.5 g herbs·kg-1) group.The volume of paw swelling was detected,and the serum levels of IL-1,IL-6,TNF-α and PGE2 were measured by ELISA.HFLS cells were treated by IL-1,generation of IL-6 and TNF-α was detected by ELISA assay.Results:Yunüjian remarkably inhibited the reduction of body weight,decreased the swelling degree of the rat paws,and decreased the concentration of inflammatory factor.Conclusion:Yunüjian has a notable anti-inflammation activity,possibly through inhibition the expression of inflammatory factors.关键词
类风湿性关节炎/佐剂性关节炎/玉女煎/抗炎/炎症因子Key words
Rheumatoid arthritis/adjuvant arthritis/Yunüjian/anti-inflammatory effect/inflammatory factor引用本文复制引用
雷莉妍,王瑞成,谢培,张丹丹,唐志书,宋忠兴..玉女煎对大鼠佐剂性关节炎的治疗作用及机制研究[J].中国现代中药,2017,19(2):196-199,213,5.基金项目
陕西中医药大学重点培育项目(2015PY08) （2015PY08）
陕西省中医管理局中医药科研基金项目(15-ZY009) （15-ZY009）
陕西省重点科技创新团队(2012KTC-20) （2012KTC-20）
陕西省科技资源开放共享平台项目(2015FWPT-01) （2015FWPT-01）
