中国现代中药2017，Vol.19Issue(3)：362-371,10.DOI:10.13313/j.issn.1673-4890.2017.3.012
雷公藤多苷肝毒性血清药物化学的初步研究
Preliminary Study on Serum Pharmacochemistry of Tripterygium Glycosides Heptotoxicity
摘要
Abstract
Objective:To study the blood components in tripterygium glycosides on liver toxicity and further explore its material basis.Methods:The objective authenticity of liver damage caused by tripterygium glycosides were evaluated by observing the liver histopathology and serum levels of AST,ALT.The fingerprint of Tripterygium glycosides UPLC-Q-TOF/MS was established by serum pharmacochemistry and MSE mode in a mass spectrometer,and the serum ingredients were identified.Results:Compared with the blank group,the rats showed statistically significant differences in liver pathomorphology and serum AST and ALT after administrated Tripterygium extract four weeks.The serum fingerprint identified 5 components include othosphenic acid,triptotriterpenic acid,demethylregelin,wilforlide and cangoronine.Conclusion: The constituents of liver toxicity of tripterygium glycosides absorbed into blood are preliminarily identified,which could lay the foundation for clarification of its materials basis.关键词
雷公藤多苷/肝毒性/血清药物化学/指纹图谱Key words
Tripterygium glycosides/liver toxicity/serum pharmacochemistry/fingerprint引用本文复制引用
王晓东,叶桃,金城,肖小河,赵奎君,蒲仕彪,马致洁..雷公藤多苷肝毒性血清药物化学的初步研究[J].中国现代中药,2017,19(3):362-371,10.基金项目
北京市中医管理局项目(QN2014-18) （QN2014-18）
首都中医药研究专项(14ZY12) （14ZY12）
北京友谊医院院启动项目(YYQDKT2014-20) （YYQDKT2014-20）
