中医药信息2017，Vol.34Issue(1)：39-43,5.
免疫性血小板减少症病证结合动物模型研究
Disease-syndrome Combined Animal Models for Immune Thrombocytopenic Purpura
摘要
Abstract
To explore the feasibility of establishing the disease-syndrome combined animal models for immune thrombocytopenic purpura (ITP) without additional conditions.Methods:Three batches of data related to the ITP model mice obtained by replication at different time were overall analyzed,and whether the APS-injected model mice replicated through the passive immune modeling method could simulate the pathogenesis and clinical characteristics of human ITP was evaluated according to the differentiation criteria for disease-syndrome combined models.Results:The APS-injected replicated ITP model mice possessed the following characteristics:①Compared with the normal group,the platelet count was significantly decreased,and coagulation time was significantly increased in the model group (P ＜ 0.01).②Compared with the normal group,the medullary thrombocytogenous megakaryocytes were significantly decreased (P ＜ 0.05,0.01,0.001).③The APS injected sites and other parts of model mice had spontaneous hemorrhage.④Behavioral changing signs were observed after 1 week of modeling,with low activity,delayed activity,poor appetite,skin petechia/hemorrhage and spontaneous hemorrhage of injected sites and other parts,and became more and more severe.Conclusion:According to the syndrome differentiation criteria for disease-syndrome combined models of ITP,the APS injected animal models of ITP replicated through the passive immune modeling method without additional conditions possess the characteristics of disease-syndrome combined models.It provides an ideal tool for the development of pharmacology experiment in traditional Chinese medicine.关键词
免疫性血小板减少症/脾(气虚)不统血证/病证结合动物模型Key words
Immune thrombocytopenic purpura/Syndrome of spleen failing to manage blood due to the spleen Qi deficiency/Disease-syndrome combined animal models分类
医药卫生引用本文复制引用
郎海燕,褚雨霆,马薇,张雅月,陈信义..免疫性血小板减少症病证结合动物模型研究[J].中医药信息,2017,34(1):39-43,5.基金项目
国家重点基础研究发展计划(973计划)(No.2013CB531705) （973计划）
