组织工程与重建外科杂志2017，Vol.13Issue(2)：70-72,81,4.DOI:10.3969/j.issn.1673-0364.2017.02.003
iRGD-外泌体-阿霉素抑制成纤维细胞体外增殖的研究
The Inhibition of iRGD-Exosomes-Doxorubicin on the Proliferation of Fibroblasts in Vitro
胡桓 1郑江红1
作者信息
- 1. 200233 上海市 上海交通大学附属第六人民医院整形外科
- 折叠
摘要
Abstract
Objective To investigate the effect and targeting of iRGD-exosomes-doxorubicin (iRGD-exo-dox) on the inhibition of the proliferation of fibroblasts. Methods The exosomes were extracted from the iRGD-transfected fibroblasts. The doxorubicin was wrapped by electroporation. Flow cytometry was used to detect the affinity of iRGD-exo-dox to fibroblasts. The ability of iRGD-exo-dox on inhibiting the proliferation of fibroblasts was analyzed. Results The affinity of iRGD-exo-dox to fibroblasts was higher than the blank-exo-dox. The proliferation of fibroblasts was obviously inhibited by iRGD-exo-dox. The inhibition effect was not observed in blank-exo-dox group. Conclusion iRGD-exo-dox can inhibit the proliferation of fibroblasts by targeting function, which can be used in the treatment of keloid.关键词
外泌体/阿霉素/瘢痕疙瘩/成纤维细胞Key words
Exosomes/Doxorubicin/Keloid/Fibroblasts分类
医药卫生引用本文复制引用
胡桓,郑江红..iRGD-外泌体-阿霉素抑制成纤维细胞体外增殖的研究[J].组织工程与重建外科杂志,2017,13(2):70-72,81,4.
