安徽医科大学学报2017，Vol.52Issue(4)：566-570,5.DOI:10.19405/j.cnki.issn1000-1492.2017.04.023
类风湿关节炎系统损害及疾病活动与血清IL-6、IL-17的相关性研究
Study on the relationship between IL-6, IL-17 andthe damage of rheumatoid arthritis and disease activity
摘要
Abstract
Objective To determine the serum levels of IL-6 and IL-17 and to explore its relationship with systemic damage and disease activity.Methods Serum IL-6 levels and IL-17 levels were measured by ELISA, and the relationship with disease activity or system involvement were analyzed.Results ① Serum levels of IL-6 and IL-17 were markedly higher in RA group than control group (P<0.01) .② The incidence rate of system impariment in RA was 68.55%, including cardiovascular 34 cases (27.42%), respiratory system 18 cases (14.52%), hematologic system 53 cases (42.74%), urinary system 14 cases (11.29%), digestive system12 cases (9.68%), endocrine system 10 cases (8.06%), nerve and skeletal system 8 cases (6.45%).③ The DAS28 and CRP levels showed higher level in patients with system impairment than without system impairment (P<0.01).Those patients who were received DMARDs standard treatment had lower incidence rate of system impairment than those without treatment (P<0.05).④ Positive correlation was detected between IL-6 or IL-17 levels and tender joint count, visual analogue scale scores of patients,erythrocyte sedimentation rate (ESR), C-reactive protein(CRP), and negative correlation was detected between IL-6 or IL-17 levels and albumin, respectively(P<0.05).Positive correlations were found between serum IL-6 and thrombocytosis, ESR and arhythmia, anemia and thrombocytosis invmultiple regression analysis.Conclusion The incidence rate of system impairment is 68.55%, and it is associated with disease activity.Serum IL-6 and IL-17 levels are correlated with disease activity and serum IL-6 level is correlated with system impairment.关键词
IL-6/IL-17/关节炎/类风湿/DAS28Key words
interleukin-6/interleukin-17/arthritis/rheumatoid/DAS28分类
医药卫生引用本文复制引用
刘娜,肖会,徐建华,黄玲玲,常玲..类风湿关节炎系统损害及疾病活动与血清IL-6、IL-17的相关性研究[J].安徽医科大学学报,2017,52(4):566-570,5.基金项目
国家自然科学基金(编号:81302587) （编号:81302587）
