安徽医科大学学报2017，Vol.52Issue(4)：589-592,4.DOI:10.19405/j.cnki.issn1000-1492.2017.04.028
掺锶透钙磷石骨水泥修复家兔牙槽骨缺损的研究
Study of repairing bone defect with strontium-containing brushite in rabbits alveolar bone
摘要
Abstract
To explore the feasibility of 5% strontium-containing brushite bone cement used as a bone defect repair material in a rabbit mandibular alveolar bone defect model.18 healthy rabbits were randomly divided into three groups.Rabbits were defected in bilateral mandibular, and the defect of blank control group without any implantation , brushite group and 5% strontium-doped brushite group were implanted brushite and 5% strontium-doped brushite respectively.The animals of each group were killed at 4, 8 weeks after operation, observing the renovation of the defect by gross observation, CBCT and immunohistochemistry.The results of CBCT indicated that the defect of 5% strontium-doped brushite group have been basically repaired at 8 weeks, partial defect of brushite group repaired , but blank control group unfinished the renovation of bone defects.Immunohistochemistry showed that the expression of OPG was highest at 4 weeks and decreased at 8 weeks.At 4 weeks and 8 weeks comparison between the three groups, the difference was statistically significant (P<0.05).The osteogenic effect of 5% strontium-doped brushite cement is viable in the renovation of rabbit alveolar bone defects, which can shorten the recovery time, and might be used as a material for repairing bone defect.关键词
牙槽骨缺损/掺锶透钙磷石/骨保护素Key words
bone defect/strontium-containing brushite/osteoprotegerin分类
医药卫生引用本文复制引用
周秋娟,梁永强,李淑静,闫玉婷,李忻畅,廖囡囡,彭宏峰,徐艳丽,戚孟春..掺锶透钙磷石骨水泥修复家兔牙槽骨缺损的研究[J].安徽医科大学学报,2017,52(4):589-592,4.基金项目
国家自然科学基金(编号:81270965) （编号:81270965）
