北京中医药大学学报2017，Vol.40Issue(4)：344-349,6.DOI:10.3969/j.issn.1006-2157.2017.04.015
治疗冠心病方剂用药规律的数据挖掘研究
Data mining of medicinal combination from Chinese medicine formula for coronary heart disease
摘要
Abstract
Objective To explore the law of medicinal combinationin traditional Chinese medicine for coronary heart disease using data mining method in order to provide reference for research and development of new drug.Methods This study built a new database based on 263 compound Chinese medicine formulas for coronary heart disease, which were selected from the National Patent Database from September 1985 to July 2015.Association rules, complex network analysis and entropy method were applied to explore the combination law of traditional Chinese compound formula using the traditional Chinese medicine inheritance system software (V2.5).Results Among the selected 263 compound formulas, the most complex one consisted of 30 herbs;the simplest,only one herb;with an average of 6.20±6.10 herbs in one formula.Activating blood and resolving stasis was the most common therapeutic principle(87 cases, 33.08%).Radix et Rhizoma Salviae Miltiorrhizae (Danshen root, Danshen) was the most frequently used herb(143 cases,54.40%);the combination of Danshen and Rhizoma Chuanxiong (Chuanxiong Rhizome, Chuanxiong), and Danshen,Chuanxiong, and Flos Carthami(Safflower, Honghua), were the most frequent couple and triple combination respectively (62, 23.57% and 33, 12.55%);Based on the association rules, frequent medicinal combination were Semen Persicae(Peach Kernel, Taoren)→Honghua(CC=0.844);Lignum Dalbergiae Odoriferae(Rosewood,Jiangxiang)→Danshen(CC=0.84);Honghua, Radix Paeoniae Rubra (red peony root,Chishao) →Chuanxiong(CC=1);Chuanxiong, Taoren→Honghua(CC=0.952).Based on complex network analysis,the core medicinals identified were Radix et Rhizoma Notoginseng(Pseudoginseng Root, Sanqi), Danshen, Honghua, Radix Angelicae Sinensis(Chinese Angelica,Danggui), Chuanxiong, Radix Astragali(Astragalus Root,Huangqi), Radix et Rhizoma Glycyrrhizae(Licorice Root, Gancao), and Radix Ophiopogonis(Dwarf Lilyturf Tube, Maidong).The new compound extracted by entropy method involved Radix Aucklandiae(Common Aucklandia Root,Muxiang), Styrax(Storax, Suhexiang) Benzoinum (Benzoin, Anxixiang), Camphora (Camphor, Zhangnao), Herba Menthae(Field Mint,Bohe), Rhizoma Alpiniae Officinarum (Galangal,Gaoliangjiang), Radix Paeoniae Alba (Galangal White Peony Root,Baishao), Pericarpium Citri Reticulatae (Citrus,Chenpi)Endothelium Corneum Gigeriae Galli (Chicken Gizzard Lining,Jineijin), and Radix Glehniae (Straight Ladybell Root,Beishashen).Conclusion This study sheds light on the combination law of Chinese medicine for coronary heart disease, and provides reference for clinical practice.关键词
冠心病/专利/关联规则/复杂网络/熵方法/用药规律/新药研发Key words
coronary heart disease/patent/association rules/complex networks/entropy method/combination rule/research and development of new drug分类
医药卫生引用本文复制引用
钟小雪,何庆勇,尹湘君,赵桂芳..治疗冠心病方剂用药规律的数据挖掘研究[J].北京中医药大学学报,2017,40(4):344-349,6.基金项目
国家自然科学基金资助项目(No.81202803),中央公益性科研院所基本科研业务费专项资金项目(No.ZZ0908023) （No.81202803）
