滨州医学院学报2017，Vol.40Issue(2)：89-93,5.
神经节苷脂佐治脑梗死疗效的Meta分析
Meta-analysis on effect of compound ganglioside injection in treating cerebral infarction
郭立莎 1林飞雪 2王现斌 1常鲁杰 3郑景辉 4杜绪强1
作者信息
- 1. 滨州医学院附属医院急诊科 滨州 256603
- 2. 广西中医药大学附属瑞康医院心内科
- 3. 滨州医学院附属医院胃镜室
- 4. 广西中医药大学附属瑞康医院科技处
- 折叠
摘要
Abstract
Objective To systematically evalutate the clinical efficacy and safty of compound ganglioside injection(GM1)in treating cerebral infarction(CI) of adults.Methods Computer retrievals were made in CNKI,VIP,Wanfang Data, Medline, Embase and relevant literature references(before October 2015),and manual retrievals were made for journals and conference papers.We collected randomized controlled trials concerning compound GM1 in the treatment of CI.The quality of included references was evaluated according to literatures recommended by Cochrane Handbook.RevMan 5.3 software was applied in the statistical treatment.Finally, a total of 36 randomized controlled trials were included,covering 2 076 patients (including 1 041 patients in the compound GM1-treated group and 1 035 patients in the control group).Results Meta-analysis results showed that the routine treatment combined with compound GM1 could improve the treatment efficiency of CI [RR =1.28, 95% CI(1.23~1.34)],improve the cure rate [RR=1.46, 95%CI(1.28~1.67)] and reduce the neurological deficit scores [MD =-9.08, 95% CI(-11.61~-6.54)] with statistical differences.Of the included studies 5 cases of skin rash appeared,7 cases of alanine Aminotransferase (GPT) increased.After stopping drugs,these above disappeared without damage to liver and kidney function.Conclusion So far,limited evidences in this study proved that the application of compound GM1 in the treatment of CI can enhance the clinical efficiency.However,because of the low quality of the included trials,more well-designed and large scale multi-center randomized controlled trials shall be made in the future.关键词
神经节苷脂/脑梗死/Meta分析Key words
ganglioside injection/cerebral Infarction/Meta analysis分类
医药卫生引用本文复制引用
郭立莎,林飞雪,王现斌,常鲁杰,郑景辉,杜绪强..神经节苷脂佐治脑梗死疗效的Meta分析[J].滨州医学院学报,2017,40(2):89-93,5.
