滨州医学院学报2017，Vol.40Issue(2)：97-99,106,4.
他克莫司联合311 nm窄谱中波紫外线治疗掌跖脓疱病疗效与安全性分析
The analysis of effect and safety of tacrolimus combined with 311 nm narrow-spectrum uvbrays to treat palmoplantar pustulosis
王学红 1薛欣欣 1董艳霞 2许文 2马强2
作者信息
- 1. 滨州医学院临床医学院 烟台 264003
- 2. 东营市人民医院皮肤科
- 折叠
摘要
Abstract
Objective To the efficacy and safety of using the method of tacrolimus combined with 311 nm narrow-spectrum uvb rays to treat palmoplantar pustulosis (PPP).Methods A total of 99 patients with moderate or severe PPP were enrolled in the study and were randomized into either the treatment group or control group.The treatment group used the method of 0.1% tacrolimus ointment combined with 311 nm narrow-spectrum uvb rays to treat PPP,the control group only for narrow spectrum uvb rays irradiation.After treatment for 2 weeks,4 weeks,6 weeks,8 weeks to determine efficacy,record adverse reactions.Results After treatment of 8 weeks the total scores of skin findings at the last observation were (2.61±1.48) in the treatment group and (3.75±1.99) in the control group,the difference was statistically significant.In particularly,the score of pustules/vesicles drastically decreased in the treatment group.In terms of safety,the incidence of adverse reactions in the treatment group and control group were 13.7% and 8.3%.There was no difference in the incidence of adverse reactions.Conclusion The treatment of tacrolimus combined 311 nm narrow-spectrum uvb rays is effective and highly safe in the management of PPP.关键词
掌跖脓疱病/他克莫司/窄谱中波紫外线/疗效/安全性Key words
palmoplantar pustulosis/tacrolimus/narrow-spectrum uvb rays/effect/security分类
医药卫生引用本文复制引用
王学红,薛欣欣,董艳霞,许文,马强..他克莫司联合311 nm窄谱中波紫外线治疗掌跖脓疱病疗效与安全性分析[J].滨州医学院学报,2017,40(2):97-99,106,4.
