滨州医学院学报2017，Vol.40Issue(2)：100-102,113,4.
胸水乳酸脱氢酶在肺腺癌并发胸腔积液患者中的临床意义
Clinical significance of pleural effusion LDH in patients with lung adenocarcinoma complicated with malignant pleural effusion
菅金波 1张鲁燕 2于泽顺 1宁方玲1
作者信息
- 1. 滨州医学院附属医院肿瘤科 滨州 256603
- 2. 滨州市人民医院肿瘤三科
- 折叠
摘要
Abstract
Objective To discuss clinical significance by measuring the effusion level of lactate dehydrogenase(LDH) in patients with lung adenocarcinoma complicated with malignant pleural effusion.Methods All of 39 cases of hospitalized patients with lung adenocarcinoma complicated with malignant pleural effusion were subjected to closed drainage of the thoracic cavity using a central venous catheter, and cisplatin reperfusion of the thoracic cavity.The patients with EGFR mutations were subjected to EGFR-TKI treatment.Additionally,the others who no EGFR mutations were accpeted conventional chemotherapy.Lactic acid substrate rate method was performed before treatment in order to monitor levels of pleural effusion LDH.All patients were followed up to after the end of treatment.Results According to the receiver operating characteristic (ROC) curve,when the cut-off value was 436.7 U/L,the sensitivity was 91.7% and the specificity was 59.3%.The mPFS of low pleural effusion LDH (≤436.7 U/L) was higher than the high pleural effusion LDH (>436.7U/L) in patients (P<0.05),the difference was statistically significant.There is no significant difference of mPFS between the conventional chemotherapy group and EGFR-TKI treatment group(P>0.05).Multivariate Cox regression analysis indicated that the level of pleural effusion LDH was an independent risk predictor for prognosis.Conclusion Detection of pleural effusion LDH in the prognosis of patients with lung adenocarcinoma complicated with malignant pleural effusion was important.关键词
乳酸脱氢酶/肺腺癌/胸腔积液/预后Key words
lactate dehydrogenase/adenocarcinoma lung/malignant pleural effusion/prognosis分类
医药卫生引用本文复制引用
菅金波,张鲁燕,于泽顺,宁方玲..胸水乳酸脱氢酶在肺腺癌并发胸腔积液患者中的临床意义[J].滨州医学院学报,2017,40(2):100-102,113,4.
