材料科学与工程学报2017，Vol.35Issue(2)：253-256,295,5.DOI:10.14136/j.cnki.issn 1673-2812.2017.02.017
PLGA/TSF静电纺纳米纤维的仿生矿化及生物相容性
Biomimetic Mineralization and Biocompatibility of PLGA/TSF Electrospun Nanofibers
摘要
Abstract
PLGA/TSF/HA electrospun nanofibers for bone tissue engineer composite scaffolds were prepared by technologies of electrospinning and simulated body fluid biomimetic mineralization.The morphology and structure of composite nanofibers were characterized by SEM,TEM,XRD and TG.Besides,hMSCs were cultured in vitro to study the biocompatible properties of composite nanofibers,which were characterized by Four methyl azo thiazole blue colorimetric (MTT) and SEM.The results indicated that PLGA/TSF nanofibers have the refined three-dimensional structure and the uniform diameter distribution with the smooth surface.HA particles uniformly distributed on the surface of PLGA/TSF nanofibers after mineralization,and the content of mineral was about 63％.The hydrophily and biocompatibility of PLGA/TSF/HA nanofiber scaffolds were significantly enhanced compared with PLGA/TSF.关键词
聚乳酸-羟基乙酸共聚物/柞蚕丝素/羟基磷灰石/生物相容性Key words
poly(lactic-co-glycolic acid) (PLGA)/tussah silk fibroin (TSF)/hydroxyapatite (HA)/Biocompatible properties分类
轻工纺织引用本文复制引用
王倩,邵伟力,高艳菲,何建新,陈利,崔世忠..PLGA/TSF静电纺纳米纤维的仿生矿化及生物相容性[J].材料科学与工程学报,2017,35(2):253-256,295,5.基金项目
国家自然科学基金资助项目(51203196,U1204510) （51203196,U1204510）
NSFC-河南人才培养联合基金资助项目(U1204510) （U1204510）
河南省教育厅科学技术研究重点资助项目(14A540003,14A540006) （14A540003,14A540006）
郑州市普通科技攻关资助项目(141PPTGG400) （141PPTGG400）
