重庆医学2017，Vol.46Issue(11)：1472-1475,4.DOI:10.3969/j.issn.1671-8348.2017.11.009
宫颈锥形切除术后宫颈组织中TNF-α、IL-6、HMGB1的表达及其意义研究
The expression and significance of TNF-α,IL-6, HMGB1 in the cervix uteri after the prior cervical conization
摘要
Abstract
Objective To investigate the dynamic changes and its significance of inflammatory factors in cervical secretions and prior cervical tissues after cervical conical resection.Methods Women who received prior cervical conization during December 2013 and December 2015 in this hospital were selected,then the cervical tissue and secretion were collected regular interval after the conization.The expression of tumor necrosis factor-α(TNF),interleukin 6 (IL-6) and high mobility group protein 1 (HMGB1) were quantitative detected and analyzed.The expression and infiltration of inflammatory cell were detected by HE and immunohistochemical staining.Results The expression of TNF-α,IL-6 and HMGB1 in cervical tissues and secretions increased gradually after priorcervical conization,which reached the peak at 1 to 2 weeks after priorcervical conization,and then gradually decreased,the differences were statistically significant when compared with the preoperative control group (P＜0.05).The inflammatory cell infiltration and the inflammatory response were most severe at 1st week after the conization.The expression of TNF-α,IL 6 and HMGB1 was at 1st week after the conization were significantly higher than that of the 4thweek group.Conclusion The cervical inflammatory were most severe after the prior cervical conization about 1-2weeks,and the hysterectomy should be avoided at this stage.关键词
子宫颈锥形切除术后/子宫切除术/肿瘤坏死因子α/白细胞介素6/高迁移率族蛋白质类/术后感染Key words
prior cervical conization/hysterectomy/tumor necrosis factor-alpha/interleukin-6/high mobility group proteins/postoperative infection分类
医药卫生引用本文复制引用
殷新明,朱小兰,温坚,朱莉,谈微微,刘颂平..宫颈锥形切除术后宫颈组织中TNF-α、IL-6、HMGB1的表达及其意义研究[J].重庆医学,2017,46(11):1472-1475,4.基金项目
国家自然科学基金项目(81402165,81672913) （81402165,81672913）
江苏省自然科学基金项目(BK20141288) （BK20141288）
江苏省镇江市科技支撑计划-社会发展基金资助项目(SH2013088). （SH2013088）
