重庆医学2017，Vol.46Issue(11)：1478-1481,4.DOI:10.3969/j.issn.1671-8348.2017.11.011
乌司他丁持续静脉泵入联合CRRT治疗MODS的临床研究
Clinical study of ulinastatin combined with CRRT in the treatment of multiple organ dysfunction syndrome
摘要
Abstract
Objective To evaluate the clinical curative effect of ulinastatin combined with CRRT in the treatment of multiple organ dysfunction syndrome(MODS).Methods Sixty eight patients with MODS who were admitted to ICU from July 2013 to July 2015 were randomly divided into three groups:control group,CRRT group,combined group;Patients' APACHE Ⅱ,SOFA scores level of inflammatory markers were recorded before treatment and after treatment of 72 hours and 7 days.The mortality of the three groups in ICU were compared.Results After 72 hours and a week of treatment,the level of IL-10,IL-6,TNF-α,WBC、PCT、CRP in CRRT group and combined group were significantly better than that of control group(P＜0.05),and combined group were significantly better than that of CRRT group.Compared with the control group,the oxygen index,lactic acid,ALT significantly im proved in CRRT group and combined group were better than control group,after 72 hours and a week of treatment(P＜0.05),and the cornbined group was the most obvious.After a week of treatment,the mortality rate of CRRT group and combined group was significantly better than the control group (P＜0.05),while there was no statistical differences between CRRT group and combined group(P＞0.05).Conclusion Ulinastatin combined with CRRT is an effective method for the treatment of MODS.关键词
乌司他丁/持续床旁血液净化治疗/多器官功能衰竭Key words
ulinastatin/continuous renal replacement therapy/multiple organ failure分类
医药卫生引用本文复制引用
亢宏山,白艳,刘亚晶,王晶,刘淑红,王会青,马珍,丁方,崔朝勃..乌司他丁持续静脉泵入联合CRRT治疗MODS的临床研究[J].重庆医学,2017,46(11):1478-1481,4.基金项目
河北省衡水市科研与发展计划项目(13012Z). （13012Z）
