摘要
Abstract
Objective To investigate the efficacy of oseltamivir in the treatment of children with seasonal influenza and its influence on serum inflammatory cytokines.Methods 96 children with seasonal influenza in our hospital from April 2015 to April 2016 were divided into two groups according to the random number table method,48 cases in each group.Two groups were given symptomatic treatment,on the basis the control group was treated with ribavirin,the observation group was treated with oral oseltamivir.The clinical efficacy,serum levels of inflammatory cytokines,and adverse reactions were compared between the two groups.Results The clinical efficacy of the observation group was better than that of the control group (93.75％ vs.79.17％),with statistically significant difference (P＜0.05).The levels of interferon gamma,tumor necrosis factor alpha,and C reactive protein of the observation group were (0.10±0.04)ng/ml,(1 744.35±70.62)pg/ml,(10.58±1.74)mg/L,significantly lower than those of the control group [(0.19-±0.08)ng/ml,(2 135.26±85.47)pg/ml,(18.3 l±2.63)mg/L],with statistically significant differences (P＜0.05).There were no obvious adverse reactions in the two groups.Conclusion Oseltamivir in the treatment of seasonal influenza in children is effective,can effectively reduce the release of inflammatory cytokines,enhance the antiviral immune function,with good safety.关键词
奥司他韦/利巴韦林/小儿/季节性流感/血清炎症因子Key words
Oseltamivir/Ribavirin/Children/Seasonal influenza/Serum inflammatory cytokines
