硅酸盐学报2017，Vol.45Issue(3)：327-332,6.DOI:10.14062/j.issn.0454-5648.2017.03.01
纳米级有序介孔氧化硅空心球的制备及药物缓释效果
Synthesis and Drug Releasing Effectiveness of Hollow Mesoporous Silica Nanospheres with Ordered Mesochannels
摘要
Abstract
The mesoporous silica solid spheres with different silica condensationdegrees inside and outside were preparedviathe hydrolysis and condensation of tetraethoxysilane (TEOS). The inner part of solid spheres is more easily dissolved rather than the outer part, and the inner part of the solid spheres is dissolved in deionized water at room temperature to obtain the hollow mesoporous silica nanospheres (HMSS) with ordered mesochannels. A facile method for preparing HMSS by water dissoving at room temperature was developed. The performance of HMSS in drug loading and releasing was investigated. The results show that this method can synthesize the HMSS with a well-defined spherical morphology, uniform particle size (i.e., 460nm), high specific surface area (i.e., 1237m2/g) and ordered mesochannels (i.e., 2.7nm), and the superior performance in drug releasing. The loading content of CPT–11 is 14.50%, and the drug releasing amount in 108h at pH 7.2, 5.5 and 4.2can reach 28.49%, 39.22% and 77.72%, respectively.关键词
介孔/氧化硅/纳米空心球/药物缓释Key words
mesoporous/silica/hollow nanosphere/drugreleasing引用本文复制引用
李世纪,马宁,张月,刘文婷,张笑妍,陈智刚,付建平,黄勇,杨金龙..纳米级有序介孔氧化硅空心球的制备及药物缓释效果[J].硅酸盐学报,2017,45(3):327-332,6.基金项目
国家自然科学基金(51572140)和中国博士后科学基金(2015M581089)资助. （51572140）
