广西医科大学学报2017，Vol.34Issue(4)：491-495,5.DOI:10.16190/j.cnki.45-1211/r.2017.04.003
牛磺酸对乳腺癌大鼠肠道菌群的影响
The influence of taurine on gut microbes in breast cancer model rats
摘要
Abstract
Objective:To investigate the effect and mechanism of taurine on gut microbes in breast cancer model rats.Methods:30 female SD rats were randomly divided into 3 groups:a control group,a 7,12-dimethylbenzanthracen (DMBA) model group and a taurine intervention group,with 10 rats in each group.The rats in the DMBA model group and the taurine intervention group were administered 1.5 g/L DMBA solution,while those in the control group were administered equal volume of peanut oil via introgastric gavage.After 16 weeks administration,the intestinal contents of rats were collected for bacterial analysis.Results:The tumour formation rate in the taurine intervention group was significantly lower than that in the DMBA model group (P ＜0.05).There was no significant difference in the species diversity of gut microbes among the three groups(P ＞0.05).Peptostreptococcus,Blautiaproducta,Streptococcus agalactiae,Enterococcus faecalis,Allobaculum,Desulfovibrionaceae,Adlercreutzia,Budding bacteria,Roseburafaecis,Mollicutes,Oscillospira were decreased in taurine intervention group compared with the DMBA model group.Conclusion:Taurine could regulate the gut microbes of breast cancer rats.This function might be related to its anti-tumor effect.关键词
牛磺酸/乳腺癌/肠道菌群Key words
taurine/breast cancer/gut microbes分类
医药卫生引用本文复制引用
欧阳轶强,宋玉美,梁柏莹,梁振鑫,郭松超,贺瑜..牛磺酸对乳腺癌大鼠肠道菌群的影响[J].广西医科大学学报,2017,34(4):491-495,5.基金项目
国家自然科学基金资助项目(No.31560612 （）
No.81260227) （）
广西科技基础条件平台建设项目(No.14-91-02) （No.14-91-02）
