广西医科大学学报2017，Vol.34Issue(4)：530-533,4.DOI:10.16190/j.cnki.45-1211/r.2017.04.012
1型和2型糖尿病患者血清HCY水平及其与糖尿病微血管并发症的关系研究
Study on the serum HCY levels in type 1 and type 2 diabetes patients and its association with diabetic microvascular complications
摘要
Abstract
Objective:To observe the difference of serum homocysteine (HCY) level between type 1 and type 2 diabetes (T1DM and T2DM) patients,and to investigate the association between HCY level and diabetic microvascular complications.Methods:From September 2015 to April 2016,26 T1DM patients (TIDM group) and 114 T2DM patients (T2DM group) treated in our hospital were selected and were subdivided into diabetic peripheral neuropathy (DPN) and diabetic nephropathy (DN) groups according to the occurrence of complications.55 healthy subjects were also selected as the healthy control group.The level of HCY in serum was measured by the circulating enzymatic method.Results:The serum HCY level in T1DM group was statistically lower than those in T2DM group and healthy control group (P ＜0.05),and no significant difference between T2DM group and healthy control group (P ＞0.05).T1DM patients combined with DPN had higher level of HCY than only T1DM ones,but still lower than the healthy controls(P ＞0.05).The HCY level of T2DM patients combined with DPN or DR was a little higher than only T2DM ones and healthy controls (P ＞0.05).Conclusion:The HCY level in T2DM patients was higher than that in T1DM ones.The elevated HCY level was associated with the occurrence of microvascular complications and it could be one of the risk factors for DN in T2DM patients.Regular monitoring of HCY level may help to understand thedisease process and prevent T2DM microvascular complications.关键词
1型糖尿病/2型糖尿病/同型半胱氨酸/糖尿病微血管并发症Key words
type 1 diabetes/type 2 diabetes/homocysteine/diabetic microvascular complications分类
医药卫生引用本文复制引用
江孔梅,李海炜,黄芝丽,陆庆华,秦雪,赖战峰..1型和2型糖尿病患者血清HCY水平及其与糖尿病微血管并发症的关系研究[J].广西医科大学学报,2017,34(4):530-533,4.基金项目
国家高技术研究发展计划(863计划)资助项目(No.2014AA022304) （863计划）
