海南医学院学报2017，Vol.23Issue(7)：865-867,871,4.DOI:10.13210/j.cnki.jhmu.20170406.066
神经病理性疼痛大鼠模型接受免疫球蛋白干预后疼痛程度及神经炎症反应程度的分析
Analysis of the pain and neuroinflammation after rats with neuropathic pain receive immunoglobulin intervention
摘要
Abstract
Objective: To study the effect of immunoglobulin intervention on the pain and neuroinflammation in rats with neuropathic pain. Methods: Wistar rats were selected as experimental animals and randomly divided into control group (Sham group), neuropathic pain model group (NP) and immunoglobulin intervention group (IG), NP group and IG group were made into neuropathic pain rat models, and the IG group received 0.4 g/kg immunoglobulin intervention. Twenty-one days after intervention, the levels of pain mediators, pro-inflammatory factors and anti-inflammatory factors in serum and spinal cord were detected. Results: Serum and spinal cord SP, 5-HT, GABA, IFN-γ, TNF-α and IL-1β levels of NP group were significantly higher than those of Sham group while serum and spinal cord IL-4 and IL-10 levels were significantly lower than those of Sham group; serum and spinal cord SP, 5-HT, GABA, IFN-γ, TNF-α and IL-1β levels of IG group were significantly lower than those of NP group while serum and spinal cord IL-4 and IL-10 levels were significantly higher than those of NP group. Conclusions: Immunoglobulin can relieve the pain and suppress the neuroinflammation in rats with neuropathic pain.关键词
神经病理性疼痛/免疫球蛋白/疼痛介质/炎症反应Key words
Neuropathic pain/Immunoglobulin/Pain mediator/Inflammation分类
医药卫生引用本文复制引用
鲁智生,周江平,刘禹利,石学银..神经病理性疼痛大鼠模型接受免疫球蛋白干预后疼痛程度及神经炎症反应程度的分析[J].海南医学院学报,2017,23(7):865-867,871,4.基金项目
国家自然科学基金号(81372103) （81372103）
It was supported by Natural Science Foundation of China (No.81372103). （No.81372103）
