海南医学院学报2017，Vol.23Issue(7)：886-889,893,5.DOI:10.13210/j.cnki.jhmu.20170116.001
缬沙坦联合阿托伐他汀对慢性心力衰竭患者心功能、心肌酶谱及甲状腺素水平的影响
Effects of valsartan combined with atorvastatin on cardiac function, myocardial enzymes and thyroxine levels in patients with chronic heart failure
摘要
Abstract
Objective: To observe the effects of valsartan combined with atorvastatin on cardiac function, myocardial enzymes and thyroxine levels in patients with chronic heart failure (CHF).Methods: A total of 90 cases of CHF cases were divided into observation group and control group according to the order of single and double number, 45 cases each.In the control group, atorvastatin was given on the basis of conventional therapy, and the observation group was given valsartan on the basis of the control group.After 6 months, the differences of cardiac function indexes (LVEF, LVEDD, LVESD, E/A), myocardial enzymes (LDH, AST, CK, CK-MB) and thyroxine (TT3, TT4, FT3, FT4, TSH) in the two groups were observed.Results: After treatment, LVEF and E/A in both groups increased significantly (P<0.05);LVEDD and LVESD decreased significantly (P<0.05);LVEF 49.05%±5.37% and E/A (1.13±0.19) are higher than the control group;LVEDD (51.55±5.26) mm and LVESD (38.87±3.61) mm are lower than the control group, the difference was statistically significant (P<0.05).After treatment, two groups of LDH, AST, CK, CK-MB were significantly decreased (P<0.05), LDH, AST, CK and CK-MB in the observation group were (165.06+29.45) IU/L, (31.51+13.33) IU/L, (96.45+29.58) mmol/L and (19.53+8.75) mmol/L, respectively, lower than the control group, the differences were statistically significant (P<0.05).After treatment, two groups of TT3 and FT3 increased significantly (P<0.05) while TT4, FT4 and TSH levels had no significant changes (P>0.05), the observation group TT3 and FT3 were (1.37+0.33) mol/L and (2.61+0.69) pmol/L, respectively, significantly higher than the control group (P<0.05).Conclusions: Valsartan combined with atorvastatin in the treatment of CHF, can improve cardiac function and myocardial protection effect, and can effectively promote the recovery of thyroid hormone levels, better than the single use of atorvastatin.关键词
慢性心力衰竭/缬沙坦/阿托伐他汀/心功能/心肌酶谱/甲状腺功能Key words
Chronic heart failure/Valsartan/Atorvastatin/Cardiac function/Myocardial enzyme/Thyroid function分类
医药卫生引用本文复制引用
汪晓刚,陈德宣,李凯..缬沙坦联合阿托伐他汀对慢性心力衰竭患者心功能、心肌酶谱及甲状腺素水平的影响[J].海南医学院学报,2017,23(7):886-889,893,5.基金项目
上海市卫计委科研项目,(编号:20151266) （编号:20151266）
It was supported by scientific research project of Health and Family Planning Commission of Shanghai with the number of 20151266. （）
